Purified anti-Transthyretin, aggregated Antibody
- 产品名称：
- Purified anti-Transthyretin, aggregated Antibody
- 产品类别：
- 抗体
- 产品编号：
- 848201
- 产品应用：
- 848201
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- A 1:1 mixture of wild-type Transthyretin fibrils and soluble aggregates of Y78F TTR.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
ELISA Capture - Quality tested
IHC-P - Verified
Direct ELISA - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by ELISA assay. For ELISA capture applications, a concentration of 2.0 ?g/ml is recommended. For immunohistochemical staining on formalin-fixed paraffin-embedded tissue sections, a concentration of is 1.0 - 5.0 ?g/ml is recommmended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone 2T5C9 recognizes a mid-region epitope on transthyretin aggregates.
- Application References
(PubMed link indicates BioLegend citation) -
- Phay M, et al. 2014. Rejuvenation Res. 17(2):97. (Direct ELISA, Capture ELISA, IHC) PubMed
- RRID
- AB_2632817 (BioLegend Cat. No. 848201) AB_2632818 (BioLegend Cat. No. 848202)
- Structure
- Transthyretin (TTR) is a β-sheet rich homotetrameric protein that has a molecular mass of 55 kD. Each monomer consists of 127 amino acids.
- Distribution
-
Primarily extracellular in blood and cerebrospinal fluid.
- Function
- The normal function of TTR is to transport thyroxine and retinol-binding protein in the blood and cerebrospinal fluid.
- Interaction
- Perlecan, receptor for advanced glycation end product (RAGE).
- Ligand/Receptor
- Thyroxine, retinol-binding protein bound to retinol.
- Cell Sources
- Liver, choroid plexus epithelium, retina pigment epithelium.
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
- Antigen References
-
1. Plante-Bordeneuve V, Said G. 2011. Lancet Neurol. 10:1086. PubMed
2. Pinney JH, et al. 2013. J. Am. Heart Assoc. 2:e000098. PubMed
3. Hawkins PN, et al. 2015. Ann Med. 47(8):625. PubMed
- Gene ID
- 7276 View all products for this Gene ID
- UniProt
- View information about Transthyretin, aggregated on UniProt.org
