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Purified anti-Bcl-X
产品名称：
Purified anti-Bcl-X
产品类别：
抗体
产品编号：
633901
产品应用：
633901
[价格]
规格 价格 库存
25µg ￥ 1212 1

产品详情

Product Details

Verified Reactivity
Human, Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Bcl-XS/L (3-14 amino acid, conserved in both human and mouse)
Formulation
This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg/ml.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
Upon receipt, store undiluted at between 2°C and 8°C.
Application

WB - Quality tested
IP - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Hsu YT, et al. 1997. J. Biol. Chem. 272:13829.
Product Citations
  1. Wang F, et al. 2020. Int J Oncol. 57:707. PubMed
  2. Inao T, et al. 2018. Oncotarget. 144:318. PubMed
RRID
AB_2064708 (BioLegend Cat. No. 633901) AB_2064706 (BioLegend Cat. No. 633902)

Antigen Details

Structure
Five alternative splicing isoforms: Bcl-XS, Bcl-XL, Bcl-Xβ, Bcl-X, Bcl-XδTM
Distribution

Bcl-XS is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-XL is found in long-lived, post-mitotic cells, such as adult brain.

Function
Bcl-X plays a critical role in the control of apoptosis. The large isoform Bcl-XL (26kD) contains the highly conserved BH1/BH2 domain and protects cells from apoptosis, whereas the short isoform, Bcl-XS (19kD), which lacks of conserved BH1/BH2 domain, promotes apoptosis by interacting with Bcl-XL and Bcl-2.
Interaction
Bcl-2, Cytochrome C, JNK1, BAG 1, Caspase 8, Caspase 9, c-FLIP, Bax, p53
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Neuroscience
Antigen References

1. Boise LH, et al. 1993 Cell 74:597

Gene ID
598 View all products for this Gene ID
UniProt
View information about BCL-X on UniProt.org

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