PE anti-mouse CD194 (CCR4) Antibody
- 产品名称：
- PE anti-mouse CD194 (CCR4) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 131203
- 产品应用：
- 131203
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Armenian Hamster
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 ?g per 106 cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application References
(PubMed link indicates BioLegend citation) -
- Saito K, et al. 2008. J. Immunol. 181:6889. PubMed
- Ueha S, et al. 2007. J. Leukoc. Biol. 82:1230. PubMed
- 3. Sharma R, et al. 2009 J. Immunol. 183:1065 (FC) PubMed
- Dogan R, et al. 2011. J. Leukoc. Biol. 89:93. PubMed
- Liu H, et al. 2011. Sci Transl Med. 3:82. PubMed.
- Shankar SP, et al. 2012. J Immunol. 188:6347. PubMed.
- Product Citations
-
- Xia S, et al. 2014. J Leukoc Biol. 95:733. PubMed
- Liu QZ, et al. 2018. Front Immunol. 1.131944444. PubMed
- Tordesillas L, et al. 2018. Nat Commun. 9:5238. PubMed
- Hayatsu N et al. 2017. Immunity. 47(2):268-283 . PubMed
- Wiesner D, et al. 2016. J Immunol. 196: 365 - 374. PubMed
- Loebbermann J, et al. 2013. Proc Natl Acad Sci U S A. 110:2987. PubMed
- Honjo A, et al. 2013. Respir Investig. 51:241. PubMed
- Morimura S, et al. 2021. Int J Mol Sci. :22. PubMed
- Zhong W, et al. 2022. Nat Commun. 13:4390. PubMed
- Meadows D, et al. 2015. PLoS One. 10: 0143738. PubMed
- Liu Y, et al. 2013. Cancer Res. 73:550. PubMed
- Suga H, et al. 2013. J Immunol. 190:6059. PubMed
- Ohsugi T, Kumasaka T 2011. PLoS One. 6:e18518. PubMed
- Zhu X et al. 2019. Cell reports. 27(4):1205-1220 . PubMed
- Rashid MH, et al. 2021. Oncol Rep. 45:1171. PubMed
- Engel I, et al. 2016. Nat Immunol. 10.1038/ni.3437. PubMed
- Lee H, et al. 2010. J Immunol. 185:6698. PubMed
- Lind L, et al. 2021. J Neurovirol. 27:145. PubMed
- Teng F, et al. 2021. Cell Rep. 37:110051. PubMed
- Moriwaki A, et al. 2011. Am J Respir Cell Mol Biol. 44:448. PubMed
- Spath S, et al. 2022. iScience. 25:104998. PubMed
- RRID
- AB_1236369 (BioLegend Cat. No. 131203) AB_1236367 (BioLegend Cat. No. 131204)
- Structure
- GPCR, chemokine receptor, seven transmembrane receptor
- Distribution
-
Memory T cells, macrophages, platelets, basophils, Th2 cells, and Tregs
- Function
- CCR4 and its ligands (CCL17 and CCL22) are important for the recruitment of memory T cells into the skin in various cutaneous immune diseases.
- Interaction
- Interaction between CCR4 and its ligand TARC/CCL17 on activated endothelial cells mediates T cell extravasation by stimulating integrin-dependent adhesion
- Ligand/Receptor
- CCl17 and CCL22
- Cell Type
- Basophils, Embryonic Stem Cells, Macrophages, Platelets, T cells, Th2, Tregs
- Biology Area
- Immunology, Stem Cells
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors, GPCR
- Antigen References
-
1. Biederman T, et al. 2002. Eur. J. Immun. 32:3171.
2. Mirshahpanah P, et al. 2008. Exp. Dermatol. 17:30.
3. Kusumoto M, et al. 2007. J. Interferon Cytokine Res 27:901.
4. Clark RA and Kupper TS. 2006. Blood 109:194.
5. Lee I, et al. 2005. J. Exp. Med. 201:1037.
- Gene ID
- 12773 View all products for this Gene ID
- UniProt
- View information about CD194 on UniProt.org
