Biotin anti-mouse CD194 (CCR4) Antibody
- 产品名称：
- Biotin anti-mouse CD194 (CCR4) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 131215
- 产品应用：
- 131215
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Armenian Hamster
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Saito K, et al. 2008. J. Immunol. 181:6889. PubMed
- Ueha S, et al. 2007. J. Leukoc. Biol. 82:1230. PubMed
- 3. Sharma R, et al. 2009 J. Immunol. 183:1065 (FC) PubMed
- Dogan R, et al. 2011. J. Leukoc. Biol. 89:93. PubMed
- Liu H, et al. 2011. Sci Transl Med. 3:82. PubMed.
- Shankar SP, et al. 2012. J Immunol. 188:6347. PubMed.
- Product Citations
-
- Cowan J, et al. 2014. J Immunol. 193:1204. PubMed
- RRID
- AB_10571205 (BioLegend Cat. No. 131215) AB_10567916 (BioLegend Cat. No. 131216)
- Structure
- GPCR, chemokine receptor, seven transmembrane receptor
- Distribution
-
Memory T cells, macrophages, platelets, basophils, Th2 cells, and Tregs
- Function
- CCR4 and its ligands (CCL17 and CCL22) are important for the recruitment of memory T cells into the skin in various cutaneous immune diseases.
- Interaction
- Interaction between CCR4 and its ligand TARC/CCL17 on activated endothelial cells mediates T cell extravasation by stimulating integrin-dependent adhesion
- Ligand/Receptor
- CCl17 and CCL22
- Cell Type
- Basophils, Embryonic Stem Cells, Macrophages, Platelets, T cells, Th2, Tregs
- Biology Area
- Immunology, Stem Cells
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors, GPCR
- Antigen References
-
1. Biederman T, et al. 2002. Eur. J. Immun. 32:3171.
2. Mirshahpanah P, et al. 2008. Exp. Dermatol. 17:30.
3. Kusumoto M, et al. 2007. J. Interferon Cytokine Res 27:901.
4. Clark RA and Kupper TS. 2006. Blood 109:194.
5. Lee I, et al. 2005. J. Exp. Med. 201:1037.
- Gene ID
- 12773 View all products for this Gene ID
- UniProt
- View information about CD194 on UniProt.org
