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FITC anti-mouse/human KLRG1 (MAFA) Antibody
产品名称：
FITC anti-mouse/human KLRG1 (MAFA) Antibody
产品类别：
抗体
产品编号：
138409
产品应用：
138409
[价格]
规格 价格 库存
25µg ￥ 1068 1

产品详情

Product Details

Verified Reactivity
Mouse, Human
Antibody Type
Monoclonal
Host Species
Syrian Hamster
Immunogen
IL-2 activated NK cells from C57BL/6 mice
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Application Notes

For successful staining of human cells, brighter fluorophore-antibody conjugates, such as PE, BV421?, or APC, are recommended.

Additional reported applications (for relevant formats) include: Western Blotting1.

Application References

(PubMed link indicates BioLegend citation)
  1. Robbins SH, et al. 2002. J. Immunol. 168:2585. (WB)
  2. Robbins SH, et al. 2003. J. Immunol. 170:5876. (FC)
  3. McMahon CW, et al. 2002. J. Immunol. 169:1444. (FC)
Product Citations
  1. Zheng X, et al. 2019. PLoS Pathog. 15:e1008036. PubMed
  2. Wang L, et al. 2019. Cell Rep. 29:1848. PubMed
  3. Pokrovskii M, et al. 2019. Immunity. 51:185. PubMed
  4. Delacher M, et al. 2021. Immunity. 54(4):702-720.e17. PubMed
  5. Plumlee CR, et al. 2020. Cell Host Microbe. 29(1):68-82.e5. PubMed
  6. Devalraju KP, et al. 2021. PLoS One. 16:e0257185. PubMed
  7. Sasaki K, et al. 2019. Nat Commun. 10:3878. PubMed
  8. Zebley CC, et al. 2021. Cell Rep. 37:109796. PubMed
  9. Dietmar Herndler‐Brandstetter et al. 2018. Immunity. 48(4):716-729 . PubMed
  10. Xu H, et al. 2020. Immunity. 51(4):696-708.e9.. PubMed
  11. Volberding PJ, et al. 2021. Cell Reports. 35(8):109160. PubMed
  12. Kennedy EM, et al. 2022. Nat Commun. 13:5907. PubMed
  13. Blaum F, et al. 2021. Life (Basel). 11:. PubMed
  14. Toshiro Hirai et al. 2019. Immunity. 50(5):1249-1261 . PubMed
  15. Moguche AO et al. 2017. Cell host & microbe. 21(6):695-706 . PubMed
  16. Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
  17. Zeis P, et al. 2020. Immunity. 53:775. PubMed
  18. Zheng Y, et al. 2022. J Immunol. 208:501. PubMed
  19. Fujimoto M, et al. 2022. Nat Commun. 13:5408. PubMed
  20. Wagner AK, et al. 2022. iScience. 25:105137. PubMed
  21. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
RRID
AB_10643998 (BioLegend Cat. No. 138409) AB_10643582 (BioLegend Cat. No. 138410)
Disclaimer

This product may be used for research purposes only.? It is not licensed for resale and may only be used by the buyer.? This product may not be used and is not licensed for clinical assays, where the results of such assays are provided as a diagnostic service.? If a diagnostic or therapeutic use is anticipated, then a license must be requested from the University of California.? The availability of such diagnostic and therapeutic use license(s) cannot be guaranteed from the University of California.

Antigen Details

Structure
KLRG1 is an inhibitory lectin-like type II transmembrane receptor containing a cytoplasmic motif similar to ITIM, expressed mainly as a homodimeric molecule consisting of two N-glycosylated subunits of approximately 30-38 kD.
Distribution

Subsets of NK cells, lymphokine-activated killer (LAK) cells and subsets of CD8+ and CD4+ cells.

Function
Regulates NK cell proliferation, maturation, and homeostasis. Inhibits immune responses by regulating the effector function and the developmental processes of NK and T cells.
Ligand/Receptor
E-cadherin
Cell Type
NK cells, T cells, Tregs
Biology Area
Immunology, Innate Immunity
Antigen References

1. Grundemann C, et al. 2006. J. Immunol. 176:1311.
2. Blaser C, et al. 1998. J. Immunol. 161:6451.
3. Huntington ND, et al. 2007. J. Immunol. 178:4764.
4. Voehringer D, et al. 2001. J. Immunol. 167:4834.

Gene ID
50928 View all products for this Gene ID
UniProt
View information about KLRG1 on UniProt.org

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