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Brilliant Violet 605™ anti-mouse/human KLRG1
产品名称：
Brilliant Violet 605™ anti-mouse/human KLRG1
产品类别：
抗体
产品编号：
138419
产品应用：
138419
[价格]
规格 价格 库存
50µg ￥ 3276 1

产品详情

Product Details

Verified Reactivity
Mouse, Human
Antibody Type
Monoclonal
Host Species
Syrian Hamster
Immunogen
IL-2 activated NK cells from C57BL/6 mice
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 605? under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Brilliant Violet 605? excites at 405 nm and emits at 603 nm. The bandpass filter 610/20 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 605? is a trademark of Sirigen Group Ltd.


Learn more about Brilliant Violet?.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser
Violet Laser (405 nm)
Application Notes

For successful staining of human cells, brighter fluorophore-antibody conjugates, such as PE, BV421?, or APC, are recommended.

Additional reported applications (for relevant formats) include: Western Blotting1.

Application References

(PubMed link indicates BioLegend citation)
  1. Robbins SH, et al. 2002. J. Immunol. 168:2585. (WB)
  2. Robbins SH, et al. 2003. J. Immunol. 170:5876. (FC)
  3. McMahon CW, et al. 2002. J. Immunol. 169:1444. (FC)
Product Citations
  1. Flamar AL, et al. 2020. Immunity. 52(4):606-619.e6.. PubMed
  2. McLane LM, et al. 2021. Cell Reports. 35(6):109120. PubMed
  3. Delacher M, et al. 2021. Immunity. 54(4):702-720.e17. PubMed
  4. Su W, et al. 2020. Cell Metabolism. 32(6):996-1011.e7. PubMed
  5. Misumi I et al. 2019. Cell Rep. 27(2):514-524 . PubMed
  6. Di Blasi D, et al. 2019. Cell Mol Gastroenterol Hepatol. 0.510416667. PubMed
  7. Li X, et al. 2019. Front Oncol. 1.115277778. PubMed
  8. Kumar MP, et al. 2018. Cell Rep. 25:1458. PubMed
  9. Toshiro Hirai et al. 2019. Immunity. 50(5):1249-1261 . PubMed
  10. Evgin L, et al. 2022. Sci Transl Med. 14:eabn2231. PubMed
  11. Yeung F, et al. 2020. Cell Host & Microbe. 27(5):809-822. PubMed
  12. Huang H, et al. 2021. Cell. 184(5):1245-1261.e21. PubMed
  13. Baja?a S, et al. 2022. iScience. 25:103732. PubMed
  14. Steinmann S, et al. 2020. Sci Rep. 1.160416667. PubMed
  15. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
RRID
AB_2563357 (BioLegend Cat. No. 138419)
Disclaimer

This product may be used for research purposes only.? It is not licensed for resale and may only be used by the buyer.? This product may not be used and is not licensed for clinical assays, where the results of such assays are provided as a diagnostic service.? If a diagnostic or therapeutic use is anticipated, then a license must be requested from the University of California.? The availability of such diagnostic and therapeutic use license(s) cannot be guaranteed from the University of California.

Antigen Details

Structure
KLRG1 is an inhibitory lectin-like type II transmembrane receptor containing a cytoplasmic motif similar to ITIM, expressed mainly as a homodimeric molecule consisting of two N-glycosylated subunits of approximately 30-38 kD.
Distribution

Subsets of NK cells, lymphokine-activated killer (LAK) cells and subsets of CD8+ and CD4+ cells.

Function
Regulates NK cell proliferation, maturation, and homeostasis. Inhibits immune responses by regulating the effector function and the developmental processes of NK and T cells.
Ligand/Receptor
E-cadherin
Cell Type
NK cells, T cells, Tregs
Biology Area
Immunology, Innate Immunity
Antigen References

1. Grundemann C, et al. 2006. J. Immunol. 176:1311.
2. Blaser C, et al. 1998. J. Immunol. 161:6451.
3. Huntington ND, et al. 2007. J. Immunol. 178:4764.
4. Voehringer D, et al. 2001. J. Immunol. 167:4834.

Gene ID
50928 View all products for this Gene ID
UniProt
View information about KLRG1 on UniProt.org

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