Biotin anti-mouse/human KLRG1 (MAFA) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
50µg	￥ 852	1

Product Details

Verified Reactivity

Mouse, Human

Antibody Type

Monoclonal

Host Species

Syrian Hamster

Immunogen

IL-2 activated NK cells from C57BL/6 mice

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.

Application

FC - Quality tested
WB - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

For successful staining of human cells, brighter fluorophore-antibody conjugates, such as PE, BV421?, or APC, are recommended.

Additional reported applications (for relevant formats) include: Western Blotting¹.

Application References (PubMed link indicates BioLegend citation)

Robbins SH, et al. 2002. J. Immunol. 168:2585. (WB)
Robbins SH, et al. 2003. J. Immunol. 170:5876. (FC)
McMahon CW, et al. 2002. J. Immunol. 169:1444. (FC)

Product Citations

Müller-Durovic B, et al. 2016. J Immunol. 197: 2891 - 2899. PubMed
del Rio ML, et al. 2021. Transl Res. Online ahead of print.. PubMed
Yang BH, et al. 2020. Cell Reports. 27(12):3629-3645.e6.. PubMed
Dekhtiarenko I, et al. 2016. PLoS Pathog. 12:e1006072. PubMed

RRID

AB_10578565 (BioLegend Cat. No. 138405) AB_10575641 (BioLegend Cat. No. 138406)

Disclaimer

This product may be used for research purposes only.? It is not licensed for resale and may only be used by the buyer.? This product may not be used and is not licensed for clinical assays, where the results of such assays are provided as a diagnostic service.? If a diagnostic or therapeutic use is anticipated, then a license must be requested from the University of California.? The availability of such diagnostic and therapeutic use license(s) cannot be guaranteed from the University of California.

Antigen Details

Structure: KLRG1 is an inhibitory lectin-like type II transmembrane receptor containing a cytoplasmic motif similar to ITIM, expressed mainly as a homodimeric molecule consisting of two N-glycosylated subunits of approximately 30-38 kD.
Distribution: Subsets of NK cells, lymphokine-activated killer (LAK) cells and subsets of CD8⁺ and CD4⁺ cells.
Function: Regulates NK cell proliferation, maturation, and homeostasis. Inhibits immune responses by regulating the effector function and the developmental processes of NK and T cells.
Ligand/Receptor: E-cadherin
Cell Type: NK cells, T cells, Tregs
Biology Area: Immunology, Innate Immunity
Antigen References: 1. Grundemann C, et al. 2006. J. Immunol. 176:1311.
2. Blaser C, et al. 1998. J. Immunol. 161:6451.
3. Huntington ND, et al. 2007. J. Immunol. 178:4764.
4. Voehringer D, et al. 2001. J. Immunol. 167:4834.
Gene ID: 50928 View all products for this Gene ID
UniProt: View information about KLRG1 on UniProt.org

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