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APC anti-mouse/human KLRG1 (MAFA) Antibody
产品名称：
APC anti-mouse/human KLRG1 (MAFA) Antibody
产品类别：
抗体
产品编号：
138411
产品应用：
138411
[价格]
规格 价格 库存
25µg ￥ 1140 1

产品详情

Product Details

Verified Reactivity
Mouse, Human
Antibody Type
Monoclonal
Host Species
Syrian Hamster
Immunogen
IL-2 activated NK cells from C57BL/6 mice
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

For successful staining of human cells, brighter fluorophore-antibody conjugates, such as PE, BV421?, or APC, are recommended.

Additional reported applications (for relevant formats) include: Western Blotting1.

Application References

(PubMed link indicates BioLegend citation)
  1. Robbins SH, et al. 2002. J. Immunol. 168:2585. (WB)
  2. Robbins SH, et al. 2003. J. Immunol. 170:5876. (FC)
  3. McMahon CW, et al. 2002. J. Immunol. 169:1444. (FC)
Product Citations
  1. Li B, Schmidt N 2016. PLoS One. 11: 0162427. PubMed
  2. Glasner A,et al. 2017. Sci Rep.. 10.1038/s41598-017-12998-w. PubMed
  3. Mackerness K, et al. 2010. J Immunol. 185:3643. PubMed
  4. Wang D, et al. 2018. Immunity. 48:659. PubMed
  5. Liu QZ, et al. 2018. Front Immunol. 1.131944444. PubMed
  6. Kobayashi T, et al. 2019. Cell. 176:982. PubMed
  7. Nagaoka M, et al. 2014. J Immunol. 193:2812. PubMed
  8. Russell SL, et al. 2019. Cell Rep. 29:3564. PubMed
  9. Dietmar Herndler‐Brandstetter et al. 2018. Immunity. 48(4):716-729 . PubMed
  10. Yadava K et al. 2019. Elife. 8 pii: e44821. PubMed
  11. White C, et al. 2015. J Immunol. 194:697. PubMed
  12. Evgin L, et al. 2022. Sci Transl Med. 14:eabn2231. PubMed
  13. Minuzzi L, et al. 2017. Eur J Appl Physiol. 10.1007/s00421-017-3600-6. PubMed
  14. Limbach K, et al. 2017. Malar J. 10.1186/s12936-017-1911-z. PubMed
  15. Wang D, et al. 2022. EMBO Rep. 23:e53691. PubMed
  16. Cao Y, et al. 2019. Nat Commun. 10:1280. PubMed
  17. Zhu G, et al. 2022. Front Microbiol. 12:806902. PubMed
  18. Pai CS, et al. 2020. Immunity. 50(2):477-492. PubMed
  19. Lu Y, et al. 2018. Cancer Cell. 33:1048. PubMed
  20. Teng F, et al. 2021. Cell Rep. 37:110051. PubMed
  21. Goc J, et al. 2021. Cell. :. PubMed
  22. Tripathi D, et al. 2016. Nat Commun. 7:13896. PubMed
RRID
AB_10645509 (BioLegend Cat. No. 138411) AB_10641560 (BioLegend Cat. No. 138412)
Disclaimer

This product may be used for research purposes only.? It is not licensed for resale and may only be used by the buyer.? This product may not be used and is not licensed for clinical assays, where the results of such assays are provided as a diagnostic service.? If a diagnostic or therapeutic use is anticipated, then a license must be requested from the University of California.? The availability of such diagnostic and therapeutic use license(s) cannot be guaranteed from the University of California.

Antigen Details

Structure
KLRG1 is an inhibitory lectin-like type II transmembrane receptor containing a cytoplasmic motif similar to ITIM, expressed mainly as a homodimeric molecule consisting of two N-glycosylated subunits of approximately 30-38 kD.
Distribution

Subsets of NK cells, lymphokine-activated killer (LAK) cells and subsets of CD8+ and CD4+ cells.

Function
Regulates NK cell proliferation, maturation, and homeostasis. Inhibits immune responses by regulating the effector function and the developmental processes of NK and T cells.
Ligand/Receptor
E-cadherin
Cell Type
NK cells, T cells, Tregs
Biology Area
Immunology, Innate Immunity
Antigen References

1. Grundemann C, et al. 2006. J. Immunol. 176:1311.
2. Blaser C, et al. 1998. J. Immunol. 161:6451.
3. Huntington ND, et al. 2007. J. Immunol. 178:4764.
4. Voehringer D, et al. 2001. J. Immunol. 167:4834.

Gene ID
50928 View all products for this Gene ID
UniProt
View information about KLRG1 on UniProt.org

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