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首页 > 抗体蛋白 > 抗体
Purified anti-mouse CD103 Antibody
产品名称：
Purified anti-mouse CD103 Antibody
产品类别：
抗体
产品编号：
121401
产品应用：
121401
[价格]
规格 价格 库存
50µg ￥ 996 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Mouse intestinal intraepithelial lymphocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IHC-F, IP - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1, immunohistochemical staining1,7 of acetone-fixed frozen sections, immunofluorescence2, and in vitro activation1.

Application References

(PubMed link indicates BioLegend citation)
  1. LeFrancois L, et. al, 1994. Eur. J. Immunol. 24:635. (FC, IHC, IP)
  2. Mysorekar IU, et. al, 2002. J. Biol. Chem. 277:37811. (FC, IF)
  3. Mikami N, et al. 2011. J. Immunol. 186:6886. PubMed
  4. del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed
  5. Quinn KM, et al. 2013. J. Immunol. 191:5085. PubMed
  6. Verhagen J and Wraith DC. 2014. J. Immunol. Methods. S0022. (FC) PubMed
  7. Xiao B, et al. 2015. PLoS One 1:e0115333. (IHC)
Product Citations
  1. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  2. Baja?a S, et al. 2021. Front Immunol. 11:577718. PubMed
  3. Mikami N, et al. 2011. J Immunol. 186:6886. PubMed
  4. Joseph R, et al. 2021. Br J Cancer. 125:176. PubMed
  5. Tian D, et al. 2020. FASEB J. 34:3367. PubMed
  6. Orecchioni M, et al. 2022. Methods Mol Biol. 2419:779. PubMed
  7. Jackson JW, et al. 2021. Mol Ther Oncolytics. 22:444. PubMed
  8. Li W, et al. 2020. J Clin Invest. 130:6718. PubMed
  9. Chudnovskiy A et al. 2016. Cell. 167(2):444-456 . PubMed
  10. Lai JF, et al. 2020. J Allergy Clin Immunol. 146:1406. PubMed
  11. Liu H, et al. 2020. J Immunol. 205:1207. PubMed
  12. Hoves S, et al. 2018. J Exp Med. 215:859. PubMed
  13. Lee JY, et al. 2018. Front Immunol. 0.678472222. PubMed
  14. Schuler CF, et al. 2020. Allergy. 75:2279. PubMed
  15. Blriot C, et al. 2021. Immunity. :. PubMed
  16. Yao Y, et al. 2017. Nat Commun. 8:15402. PubMed
  17. Janela B, et al. 2019. Immunity. 50:1069. PubMed
  18. Gubin MM, et al. 2018. Cell. 175:1014. PubMed
  19. Ford J, et al. 2019. Front Immunol. 2.502083333. PubMed
  20. Jordan S, et al. 2020. Cell. 178(5):1102-1114.e17.. PubMed
  21. Bengsch B et al. 2018. Immunity. 48(5):1029-1045 . PubMed
  22. Vander B, et al. 2017. J Cell Biol. 10.1083/jcb.201512012. PubMed
  23. McClellan BL, et al. 2022. STAR Protoc. 3:101357. PubMed
  24. Xu W, et al. 2021. Immunity. 54(3):526-541.e7. PubMed
  25. Maier B, et al. 2020. Nature. 580:257. PubMed
  26. K?stele V, et al. 2021. Mucosal Immunol. 14:717. PubMed
RRID
AB_535944 (BioLegend Cat. No. 121401) AB_535945 (BioLegend Cat. No. 121402)

Antigen Details

Structure
Type I transmembrane glycoprotein, Integrin family, can be cleaved into 150 kD and 25 kD chains, associated with β7 integrin
Distribution

Majority of intestinal intraepithelial lymphocytes (IEL), subpopulation of lamina propria T cells, epithelial dendritic cells, small subset of peripheral lymphocytes, Treg cells.

Function
Retention and activation of CD103+ lymphocytes in the intestinal epithelium, regulate tissue-specific T cell homing.
Ligand/Receptor
E-Cadherin
Cell Type
Dendritic cells, Lymphocytes, T cells, Tregs
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Kilshaw PJ and SJ. Murant. 1990. Eur. J. Immunol. 20:2201.
2. Karecla PI, et al. 1995. Eur. J. Immunol. 25:852.
3. LeFrancois L, et al. 1994. Eur. J. Immunol. 24:635.
4. Sung SS, et al. 2006. J. Immunol. 176:2161.
5. Johansson-Lindbom B, et al. 2005. J. Exp. Med. 202:1063.
6. Dujardin HC, et al. 2004. Proc. Natl. Acad. Sci. USA. 101:14473.

Gene ID
16407 View all products for this Gene ID
UniProt
View information about CD103 on UniProt.org

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