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首页 > 抗体蛋白 > 抗体
PE/Cyanine7 anti-mouse CD103 Antibody
产品名称：
PE/Cyanine7 anti-mouse CD103 Antibody
产品类别：
抗体
产品编号：
121425
产品应用：
121425
[价格]
规格 价格 库存
25µg ￥ 1908 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Mouse intestinal intraepithelial lymphocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.65 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1, immunohistochemical staining1,7 of acetone-fixed frozen sections, immunofluorescence2, and in vitro activation1.

Additional Product Notes
BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.
Application References

(PubMed link indicates BioLegend citation)
  1. LeFrancois L, et. al, 1994. Eur. J. Immunol. 24:635. (FC, IHC, IP)
  2. Mysorekar IU, et. al, 2002. J. Biol. Chem. 277:37811. (FC, IF)
  3. Mikami N, et al. 2011. J. Immunol. 186:6886. PubMed
  4. del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed
  5. Quinn KM, et al. 2013. J. Immunol. 191:5085. PubMed
  6. Verhagen J and Wraith DC. 2014. J. Immunol. Methods. S0022. (FC) PubMed
  7. Xiao B, et al. 2015. PLoS One 1:e0115333. (IHC)
Product Citations
  1. Heindl S, et al. 2021. J Exp Med. 218:. PubMed
  2. de Mingo Pulido , et al. 2021. Immunity. 54(6):1154-1167.e7. PubMed
  3. Acharya N, et al. 2020. Immunity. 53(3):658-671.e6. PubMed
  4. Chow MT et al. 2019. Immunity. 50(6):1498-1512 . PubMed
  5. ?lvaro de Mingo Pulido et al. 2018. Cancer cell. 33(1):60-74 . PubMed
  6. Antunes KH, et al. 2022. Front Immunol. 13:867022. PubMed
  7. Ontiveros-Padilla L, et al. 2021. Microorganisms. 9:. PubMed
  8. Sandborn WJ, et al. 2021. Gastroenterology. 161:1853. PubMed
  9. Lamubol J, et al. 2021. Food Funct. 12:8044. PubMed
  10. Zhou Y, et al. 2022. Nat Commun. 13:2906. PubMed
  11. Len-Letelier RA, et al. 2020. Frontiers in Immunology. 11:583382. PubMed
  12. Hernández–Santos N, et al. 2018. Cell Host Microbe. 1.313194444. PubMed
  13. Milner JJ, et al. 2020. Immunity. 52(5):808-824.e7. PubMed
  14. Niknam S, et al. 2018. Clin Cancer Res. 24:5735. PubMed
  15. Reinfeld BI, et al. 2021. Nature. 593:282. PubMed
  16. Li C, et al. 2020. Immunity. 52(1):201-202. PubMed
  17. Seki T, et al. 2015. J Biochem. 158: 485 - 495. PubMed
  18. Younes AI, et al. 2021. Transl Oncol. 14:100983. PubMed
  19. Guendel F, et al. 2020. Immunity. 53(5):1015-1032.e8. PubMed
  20. Hoover AR, et al. 2022. Clin Transl Med. 12:e937. PubMed
  21. Gardner A, et al. 2022. J Immunother Cancer. 10:. PubMed
  22. Celias DP, et al. 2022. STAR Protoc. 3:101464. PubMed
  23. Chang MH, et al. 2021. Cell Rep. 37:109902. PubMed
RRID
AB_2563690 (BioLegend Cat. No. 121425) AB_2563691 (BioLegend Cat. No. 121426)

Antigen Details

Structure
Type I transmembrane glycoprotein, Integrin family, can be cleaved into 150 kD and 25 kD chains, associated with β7 integrin
Distribution

Majority of intestinal intraepithelial lymphocytes (IEL), subpopulation of lamina propria T cells, epithelial dendritic cells, small subset of peripheral lymphocytes, Treg cells.

Function
Retention and activation of CD103+ lymphocytes in the intestinal epithelium, regulate tissue-specific T cell homing.
Ligand/Receptor
E-Cadherin
Cell Type
Dendritic cells, Lymphocytes, T cells, Tregs
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Kilshaw PJ and SJ. Murant. 1990. Eur. J. Immunol. 20:2201.
2. Karecla PI, et al. 1995. Eur. J. Immunol. 25:852.
3. LeFrancois L, et al. 1994. Eur. J. Immunol. 24:635.
4. Sung SS, et al. 2006. J. Immunol. 176:2161.
5. Johansson-Lindbom B, et al. 2005. J. Exp. Med. 202:1063.
6. Dujardin HC, et al. 2004. Proc. Natl. Acad. Sci. USA. 101:14473.

Gene ID
16407 View all products for this Gene ID
UniProt
View information about CD103 on UniProt.org

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