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首页 > 抗体蛋白 > 抗体
PE anti-mouse CD103 Antibody
产品名称：
PE anti-mouse CD103 Antibody
产品类别：
抗体
产品编号：
121405
产品应用：
121405
[价格]
规格 价格 库存
25µg ￥ 876 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Mouse intestinal intraepithelial lymphocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1, immunohistochemical staining1,7 of acetone-fixed frozen sections, immunofluorescence2, and in vitro activation1.

Application References

(PubMed link indicates BioLegend citation)
  1. LeFrancois L, et. al, 1994. Eur. J. Immunol. 24:635. (FC, IHC, IP)
  2. Mysorekar IU, et. al, 2002. J. Biol. Chem. 277:37811. (FC, IF)
  3. Mikami N, et al. 2011. J. Immunol. 186:6886. PubMed
  4. del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed
  5. Quinn KM, et al. 2013. J. Immunol. 191:5085. PubMed
  6. Verhagen J and Wraith DC. 2014. J. Immunol. Methods. S0022. (FC) PubMed
  7. Xiao B, et al. 2015. PLoS One 1:e0115333. (IHC)
Product Citations
  1. Parsons M, et al. 2014. J Immunol. 192:1361. PubMed
  2. Koyama M, et al. 2015. J Exp Med. 212: 1303 - 1321. PubMed
  3. Bruand M, et al. 2021. Cell Reports. 36(3):109412. PubMed
  4. Ramakrishna C, et al. 2019. Nat Commun. 10:2153. PubMed
  5. Oliver AJ, et al. 2020. Oncoimmunology. 9:1802979. PubMed
  6. Gonalves S, et al. 2021. Cell Reports. 34(11):108860. PubMed
  7. Kim S, et al. 2020. Immunity. 53(4):759-774.e9. PubMed
  8. Rezende R, et al. 2015. Nat Commun. 6: 8726. PubMed
  9. Vogel AJ et al. 2015. Frontiers in immunology. 0.477083333 . PubMed
  10. Schloss MJ, et al. 2022. Nat Immunol. 23:605. PubMed
  11. Barry KC, et al. 2018. Nat Med. 24:1178. PubMed
  12. Almeida AS, et al. 2021. Bio Protoc. 11:e4012. PubMed
  13. Devalaraja S, et al. 2020. Cell. 1098:180. PubMed
  14. Tordesillas L, et al. 2018. Nat Commun. 9:5238. PubMed
  15. Vereertbrugghen A, et al. 2021. Front Oncol. 11:598319. PubMed
  16. Yu AI, et al. 2020. Cell Rep. 107471:31. PubMed
  17. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  18. Best SA, et al. 2018. Cell Metab. 27:935. PubMed
  19. Wang C, et al. 2021. Cell Rep. 37:110021. PubMed
  20. Hao F, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  21. Almeida AS, et al. 2021. Bio Protoc. 11:e4012. PubMed
  22. Wang Y, et al. 2021. Sci Rep. 1.429861111. PubMed
  23. Hartwig T et al. 2018. Cell reports. 25(13):3564-3572 . PubMed
  24. Stump CT, et al. 2021. Open Biol. 11:210245. PubMed
  25. Hulsmans M et al. 2017. Cell. 169(3):510-522 . PubMed
  26. Schadt L, et al. 2020. Cell Reports. 29(5):1236-1248.e7.. PubMed
  27. Ahadome S, et al. 2016. JCI Insight. 1:e87012. PubMed
  28. Frodermann V, et al. 2019. Nat Med. 25:1761. PubMed
  29. Garo LP, et al. 2019. Cell Rep. 28:3353. PubMed
  30. Crooks SD, et al. 2022. Immunohorizons. 6:705. PubMed
  31. Van Braeckel-Budimir N, et al. 2018. Cell Rep. 24:3374. PubMed
  32. Murakami R, et al. 2013. PLoS One. 8:73270. PubMed
  33. Kyburz A, et al. 2019. J Allergy Clin Immunol. 143:1496. PubMed
  34. De Ponte Conti B, et al. 2021. Elife. 10:. PubMed
  35. Chandra J, et al. 2016. Immunol Cell Biol. 10.1038/icb.2016.83. PubMed
  36. Alam Z, et al. 2020. Cell Rep. 107825:31. PubMed
  37. Beura LK, et al. 2018. Immunity. 48:327. PubMed
  38. Katagiri T, et al. 2019. Mucosal Immunol. 12:p1104. PubMed
  39. Tuong ZK, et al. 2021. iScience. 24:103326. PubMed
  40. Guo S, et al. 2021. Sci Rep. 11:23745. PubMed
  41. Nelson CE et al. 2019. Cell Rep. 28(12):3092-3104 . PubMed
  42. Stephens WZ, et al. 2021. Cell Rep. 37:109916. PubMed
  43. Zhang XW, et al. 2021. Oncoimmunology. 10:1920739. PubMed
  44. Calderon B, et al. 2015. J Exp Med. 212: 1497-1512. PubMed
  45. Keerthivasan S, et al. 2021. Immunity. 54(7):1511-1526.e8. PubMed
  46. Carlson PM, et al. 2021. J Immunol. 207:720. PubMed
  47. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  48. Yamazaki S, et al. 2015. J Immunol. 195: 3427 - 3435. PubMed
  49. Bonavita E, et al. 2020. Immunity. 1215:53. PubMed
  50. Wan X, Thomas J, Unanue E 2016. J Exp Med. 213: 967 - 978. PubMed
  51. Jin J, et al. 2020. Cell Reports. 30(12):4124-4136. PubMed
  52. Tran S, et al. 2020. Immunity. 53(3):627-640.e5. PubMed
  53. Tian T, et al. 2020. Cancer Immunol Res. 660:8. PubMed
  54. Lai NY, et al. 2020. Cell. 180:33:00. PubMed
  55. Guo S, et al. 2021. Frontiers in Immunology. 11:614667. PubMed
  56. Thomson CA, et al. 2018. J Immunol. 201:215. PubMed
  57. Chang MH, et al. 2021. Cell Rep. 37:109902. PubMed
RRID
AB_535948 (BioLegend Cat. No. 121405) AB_1133989 (BioLegend Cat. No. 121406)

Antigen Details

Structure
Type I transmembrane glycoprotein, Integrin family, can be cleaved into 150 kD and 25 kD chains, associated with β7 integrin
Distribution

Majority of intestinal intraepithelial lymphocytes (IEL), subpopulation of lamina propria T cells, epithelial dendritic cells, small subset of peripheral lymphocytes, Treg cells.

Function
Retention and activation of CD103+ lymphocytes in the intestinal epithelium, regulate tissue-specific T cell homing.
Ligand/Receptor
E-Cadherin
Cell Type
Dendritic cells, Lymphocytes, T cells, Tregs
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Kilshaw PJ and SJ. Murant. 1990. Eur. J. Immunol. 20:2201.
2. Karecla PI, et al. 1995. Eur. J. Immunol. 25:852.
3. LeFrancois L, et al. 1994. Eur. J. Immunol. 24:635.
4. Sung SS, et al. 2006. J. Immunol. 176:2161.
5. Johansson-Lindbom B, et al. 2005. J. Exp. Med. 202:1063.
6. Dujardin HC, et al. 2004. Proc. Natl. Acad. Sci. USA. 101:14473.

Gene ID
16407 View all products for this Gene ID
UniProt
View information about CD103 on UniProt.org

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