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APC anti-mouse CD103 Antibody
产品名称:
APC anti-mouse CD103 Antibody
产品类别:
抗体
产品编号:
121413
产品应用:
121413
[价格]
规格 价格 库存
25µg ¥ 1284 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Mouse intestinal intraepithelial lymphocytes
Formulation
Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1, immunohistochemical staining1,7 of acetone-fixed frozen sections, immunofluorescence2, and in vitro activation1.

Application References

(PubMed link indicates BioLegend citation)
  1. LeFrancois L, et. al, 1994. Eur. J. Immunol. 24:635. (FC, IHC, IP)
  2. Mysorekar IU, et. al, 2002. J. Biol. Chem. 277:37811. (FC, IF)
  3. Mikami N, et al. 2011. J. Immunol. 186:6886. PubMed
  4. del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed
  5. Quinn KM, et al. 2013. J. Immunol. 191:5085. PubMed
  6. Verhagen J and Wraith DC. 2014. J. Immunol. Methods. S0022. (FC) PubMed
  7. Xiao B, et al. 2015. PLoS One 1:e0115333. (IHC)
Product Citations
  1. Koyama M, et al. 2015. J Exp Med. 212: 1303 - 1321. PubMed
  2. Garber C, et al. 2019. Nat Neurosci. 1.802777778. PubMed
  3. Zheng X, et al. 2019. PLoS Pathog. 15:e1008036. PubMed
  4. Kimura S, et al. 2020. Nat Commun. 0.620833333. PubMed
  5. Bruggemann TR, et al. 2022. iScience. 25:105185. PubMed
  6. Ren Z, et al. 2021. EMBO Molecular Medicine. :e14059. PubMed
  7. Fachi JL et al. 2019. Cell reports. 27(3):750-761 . PubMed
  8. Dong L, et al. 2021. Cancer Cell. . PubMed
  9. Barry KC, et al. 2018. Nat Med. 24:1178. PubMed
  10. Aldon Y, et al. 2020. J Immunol. 204:903. PubMed
  11. Sng XYX, et al. 2020. J Immunol. 204:3108. PubMed
  12. Wu J, et al. 2020. Cell Reports. 31(1):107484. PubMed
  13. Li Y, et al. 2020. Cell Rep. 30:1753. PubMed
  14. Rao S, et al. 2017. Cell. 168(3):503-516.e12. PubMed
  15. Okamoto T, et al. 2020. Cancer Res. 3580:80. PubMed
  16. Ostendorf BN, et al. 2020. Nat Med. 26:1048. PubMed
  17. Fujita Y et al. 2018. Cell reports. 24(12):3296-3311 . PubMed
  18. Kawakami R, et al. 2021. Immunity. 54(5):947-961.e8. PubMed
  19. Ruhland MK, et al. 2020. Cancer Cell. 37(6):786-799.e5. PubMed
  20. Wu L, et al. 2022. Theranostics. 12:842. PubMed
  21. Cassidy BR, et al. 2020. J Neuroinflammation. 17:259. PubMed
  22. Gozgit JM, et al. 2021. Cancer Cell. :. PubMed
  23. Garo LP, et al. 2019. Cell Rep. 28:3353. PubMed
  24. Tavazoie MF, et al. 2018. Cell. 172:825. PubMed
  25. Place D, et al. 2017. PLoS One. 10.1371/journal.pone.0190384. PubMed
  26. Gabriel SS, et al. 2021. Immunity. 54(8):1698-1714.e5. PubMed
  27. Jin C, et al. 2019. Cell. 176:998. PubMed
  28. Nam GH, et al. 2018. Nat Commun. 9:2165. PubMed
  29. Jin C, et al. 2022. Oncoimmunology. 11:2099642. PubMed
  30. Yamada D, et al. 2014. J Immunol. 192:4112. PubMed
  31. Morikawa M, et al. 2016. PLoS One. 11:e0163607. PubMed
  32. Kim M, et al. 2018. Immunity. 49:151. PubMed
  33. Dallari S, et al. 2021. Cell Host Microbe. 29(6):1014-1029.e8. PubMed
  34. Amezcua Vesely MC, et al. 2020. Cell. 178(5):1176-1188.e15.. PubMed
  35. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  36. Xiao Y, et al. 2021. Cell. 184:6037. PubMed
  37. Stefan KL, et al. 2020. Cell. 1312:183. PubMed
  38. Bonavita E, et al. 2020. Immunity. 1215:53. PubMed
  39. Li J, et al. 2021. Cell Reports. 34(11):108839. PubMed
  40. Yu H, et al. 2015. PLoS One. 10: 0143001. PubMed
  41. Tran S, et al. 2020. Immunity. 53(3):627-640.e5. PubMed
  42. Katsuyama T, et al. 2021. Cell Reports. 36(1):109339. PubMed
  43. Wu L, et al. 2020. Cancer Immunol Res. 710:8. PubMed
  44. Dai B, et al. 2021. Cell Reports Medicine. 2(8):100381. PubMed
  45. Chng S, et al. 2016. Sci Rep. 6: 23820. PubMed
  46. Paiva C, et al. 2010. Rheumatology. 49:246. PubMed
  47. Riopel M, et al. 2019. Mol Metab. 20:89. PubMed
  48. Pan Y, et al. 2021. NPJ Vaccines. 6:1. PubMed
RRID
AB_1227503 (BioLegend Cat. No. 121413) AB_1227502 (BioLegend Cat. No. 121414)

Antigen Details

Structure
Type I transmembrane glycoprotein, Integrin family, can be cleaved into 150 kD and 25 kD chains, associated with β7 integrin
Distribution

Majority of intestinal intraepithelial lymphocytes (IEL), subpopulation of lamina propria T cells, epithelial dendritic cells, small subset of peripheral lymphocytes, Treg cells.

Function
Retention and activation of CD103+ lymphocytes in the intestinal epithelium, regulate tissue-specific T cell homing.
Ligand/Receptor
E-Cadherin
Cell Type
Dendritic cells, Lymphocytes, T cells, Tregs
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Kilshaw PJ and SJ. Murant. 1990. Eur. J. Immunol. 20:2201.
2. Karecla PI, et al. 1995. Eur. J. Immunol. 25:852.
3. LeFrancois L, et al. 1994. Eur. J. Immunol. 24:635.
4. Sung SS, et al. 2006. J. Immunol. 176:2161.
5. Johansson-Lindbom B, et al. 2005. J. Exp. Med. 202:1063.
6. Dujardin HC, et al. 2004. Proc. Natl. Acad. Sci. USA. 101:14473.

Gene ID
16407 View all products for this Gene ID
UniProt
View information about CD103 on UniProt.org

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