APC anti-human CD45 Antibody
- 产品名称：
- APC anti-human CD45 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 368511
- 产品应用：
- 368511
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human PBMC
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Red Laser (633 nm)
- Application Notes
It was found that the HI30 clone and the 2D1 clone can cross block each other's binding.
- Application References
(PubMed link indicates BioLegend citation) -
- Bradstock KF, et al. 1980. J. Natl. Cancer Inst. 65:33.
- Csiba A, et al. 1984. Br. J. Cancer 50:699.
- Tchilian EZ, et al. 2001. J. Immunol. 166:1308.
- Lee MS, et al. 2004. Int. Immunol. 16:1109.
- Product Citations
-
- Zhou Y, et al. 2020. Cancer Cell. 38(6):818-828.e5. PubMed
- Govaerts I, et al. 2021. J Hematol Oncol. 14:97. PubMed
- Boyd DF, et al. 2020. Nature. 587:466. PubMed
- Galán-Díez M, et al. 2022. Cancer Discov. . PubMed
- Marinaccio C, et al. 2021. Cancer Discovery. 11(6):1398-1410. PubMed
- Jiang S, et al. 2021. Bioact Mater. 2711:6. PubMed
- Azizi E et al. 2018. Cell. 174(5):1293-1308 e36. PubMed
- Kim JT, et al. 2022. Nat Commun. 13:121. PubMed
- Antonucci L, et al. 2020. Journal of Immunology Research. 3257.929861. PubMed
- Hansen IS, et al. 2018. Nat Commun. 9:863. PubMed
- Liu S, et al. 2021. Mol Ther. 29:1918. PubMed
- Choi J, et al. 2021. Nat Cell Biol. 23:953. PubMed
- Celik H, et al. 2021. Cancer Discov. 11:3126. PubMed
- Chen D, et al. 2021. Molecular Cell. :. PubMed
- Gao P, et al. 2017. Cytotechnology. 69:751. PubMed
- Qian SJ, et al. 2021. Front Immunol. 12:711337. PubMed
- Li J, et al. 2021. Mol Med Rep. 1:23. PubMed
- Wegner J, et al. 2021. Sci Rep. 11:14983. PubMed
- Sun J et al. 2018. Cell stem cell. 23(3):355-369 . PubMed
- Yoshida R, et al. 2022. Cancer Res. :. PubMed
- Lee JK, et al. 2021. Cells. 10:. PubMed
- Celik H, et al. 2018. Cancer Cell. 34:741. PubMed
- Lin KH, et al. 2020. Nat Genet. 52:408. PubMed
- Krivtsov AV, et al. 2020. Cancer Cell. 36(6):660-673.e11.. PubMed
- Dou D, et al. 2016. Nat Cell Biol. 18: 595-606. PubMed
- Wang J, et al. 2020. Cell Stem Cell. 27(1):81-97. PubMed
- Yang X, et al. 2020. Immunity. 51(6):983-996.e6.. PubMed
- Mahajan A, et al. 2019. J Leukoc Biol. 105:1087. PubMed
- Chijimatsu R, et al. 2022. Regen Ther. 21:52. PubMed
- RRID
- AB_2566371 (BioLegend Cat. No. 368511) AB_2566372 (BioLegend Cat. No. 368512)
- Structure
- Type I transmembrane protein, 180 - 240 kD (multiple isoforms)
- Distribution
-
Hematopoietic cells, except circulating erythrocytes or platelets.
- Function
- Tyrosine phosphatases, signaling, co-stimulation (co-inhibition), TCR and BCR mediated activation.
- Ligand/Receptor
- Galectin-1, CD2, CD3, and CD4.
- Cell Type
- B cells, Dendritic cells, Neutrophils
- Biology Area
- Cell Biology, Immunology, Inhibitory Molecules, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- CD Molecules, Protein Kinases/Phosphatase, TCRs
- Antigen References
-
1. Thomas M. 1989. Annu. Rev. Immunol. 7:339.
2. Trowbridge I, et al. 1994. Annu. Rev. Immunol. 12:85.
- Gene ID
- 5788 View all products for this Gene ID
- UniProt
- View information about CD45 on UniProt.org
