Purified anti-SMN (Gemin 1) Antibody
- 产品名称：
- Purified anti-SMN (Gemin 1) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 862801
- 产品应用：
- 862801
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC, IHC-F - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Kobayashi M, et al. 2017. Disease Models & Mechanisms. (10):215 (IHC-F)
- Spiro Z, et al. 2016. Scientific Reports. (6):27470 (ICC)
- Yong J, et al. 2004. Molecular and Cellular Biology. 24(7):2747 (WB)
- RRID
- AB_2810753 (BioLegend Cat. No. 862801) AB_2810754 (BioLegend Cat. No. 862802)
- Structure
- SMN1 is a 294 amino acid protein with an apparent molecular mass of ~ 32 kD.
- Distribution
-
Tissue Distribution: Brain, pancreas, gallbladder, bladder, testis, lymph node, and bone marrow
Cellular Distribution: Nucleus and cytosol
- Function
- SMN1 is a component of the SMN complex essential for the formation of snRNP complexes in Eukaryotic cells.
- Interaction
- SMN1 forms homodimers or found in complex with other SMN/GEMIN proteins.
- Cell Type
- Neurons
- Biology Area
- Chromatin Remodeling/Epigenetics, Neurodegeneration, Neuroscience, Synaptic Biology, Transcription Factors
- Antigen References
-
- Maretina MA, et al. 2018. Curr Genomics. 19(5):339
- Singh RN, et al. 2018. Adv Neurobiol. 20:31
- Groen EJN, et al. 2018. Nat Rev Neurol. 14(4):214
- Gene ID
- 6606 View all products for this Gene ID 6607 View all products for this Gene ID
- UniProt
- View information about SMN on UniProt.org
