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首页 > 抗体蛋白 > 抗体
Purified anti-mouse CD279 (PD-1) Antibody
产品名称：
Purified anti-mouse CD279 (PD-1) Antibody
产品类别：
抗体
产品编号：
135202
产品应用：
135202
[价格]
规格 价格 库存
500µg ￥ 1632 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
PD-1 cDNA followed by PD-1-Ig fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IHC-F - Verified
Block - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 ?g per million cells in 100 ?L?volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue3, in vivo blocking of PD-1 binding to its ligands2,3, and spatial biology (IBEX)5,6.

Application References

(PubMed link indicates BioLegend citation)
  1. Good-Jacobson KL, et al. 2010. Nat. Immunol. 11:535. (FC) PubMed
  2. Lázár-Molnár E, et al. 2008. Proc. Natl. Acad. Sci. USA 105:2658. (Block)
  3. Liang SC, et al. 2003. Eur. J. Immunol. 33:2706. (FC, IHC, Block)
  4. Tobias J, et al. 2020. Front Immunol. 11:895 (FC, ELISA) PubMed
  5. Radtke?AJ,?et al.?2020.?Proc Natl Acad Sci U S A.?117:33455-65. (SB)?PubMed
  6. Radtke?AJ,?et al.?2022.?Nat Protoc.?17:378-401. (SB)?PubMed
Product Citations
  1. Morales-Molina A, et al. 2020. Cancers (Basel). 12:. PubMed
  2. Kobayashi A, et al. 2021. Front Immunol. 12:650856. PubMed
  3. Chartrand K, et al. 2018. Front Immunol. 1.642361111. PubMed
  4. Shirakawa K, et al. 2017. PLoS One. 12:e0186303. PubMed
  5. Ajona D, et al. 2017. Cancer Discov. 0.773611111. PubMed
  6. Goel S, et al. 2017. Nature. 548:471. PubMed
  7. Wang W, et al. 2018. Cancer Cell. 34:757. PubMed
  8. Wang J, et al. 2021. Cancers (Basel). 13:. PubMed
  9. Imazeki H, et al. 2021. J Immunother Cancer. 9:. PubMed
  10. Carpenter SM, et al. 2017. PLoS Pathog. 13:e1006704. PubMed
  11. Haque M, et al. 2021. Viruses. 13:. PubMed
  12. Son YM, et al. 2020. Eur J Immunol. 50:1067. PubMed
  13. Wang Y, et al. 2021. Cancer Cell. :. PubMed
  14. Xie MM, et al. 2017. Eur J Immunol. 47:1136. PubMed
  15. Joseph R, et al. 2021. Br J Cancer. 125:176. PubMed
  16. Muhammad F, et al. 2020. Front Immunol. 975:11. PubMed
  17. Jackson JW, et al. 2021. Mol Ther Oncolytics. 22:444. PubMed
  18. Mayer KA, et al. 2021. FASEB J. 35:e21217. PubMed
  19. Wang J, et al. 2017. Cancer Prev Res (Phila). 10:684. PubMed
  20. Fiege JK, et al. 2019. PLoS Pathog. 15:e1008077. PubMed
  21. Hilligan KL, et al. 2020. Nat Commun. 11:5637. PubMed
  22. Oba T, et al. 2021. J Immunother Cancer. 9:. PubMed
  23. Sato Y, et al. 2021. BMC Cancer. 21:1222. PubMed
  24. Huang B, et al. 2015. PLoS One. 10: 0134715. PubMed
  25. Kinosada H, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006120. PubMed
  26. Gilfillan CB, et al. 2020. Eur J Immunol. 50:505. PubMed
  27. Karmaus PWF, et al. 2019. Nature. 565:101. PubMed
  28. Muhammad F, et al. 2020. J Autoimmun. 111:102441. PubMed
  29. Flietner E, et al. 2022. Sci Rep. 12:10616. PubMed
  30. Roussey JA, et al. 2017. J Immunol. 199:3535. PubMed
  31. Wang M, et al. 2022. Front Pharmacol. 13:887457. PubMed
  32. Cané S, et al. 2021. J Immunother Cancer. 9:. PubMed
  33. Pushalkar S, et al. 2018. Cancer Discov. 0.613194444. PubMed
RRID
AB_1877121 (BioLegend Cat. No. 135202)

Antigen Details

Structure
A 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily.
Distribution

Induced on splenic T and B lymphocytes, thymocytes, and myeloid cells after stimulation.

Function
Involved in lymphocyte clonal selection and peripheral tolerance, prolonged survival of allografts.
Ligand/Receptor
B7-H1 (PD-L1) and B7-DC (PD-L2)
Cell Type
B cells, T cells
Biology Area
Cancer Biomarkers, Immunology, Inhibitory Molecules
Molecular Family
CD Molecules, Immune Checkpoint Receptors
Antigen References

1. Nishimura H, et al. 2001. Science 291:319
2. Agata Y, et al. 1996. Int. Immunol. 8:765
3. Liang SC, et al. 2003. Eur. J. Immunol. 33:2706
4. Barber DL, et al. 2006. Nature 439:682
5. Keir ME, et al. 2005. J. Immunol. 175:7372
6. Koehn BH. et al. 2008. J Immunol. 181:5313

Gene ID
18566 View all products for this Gene ID
UniProt
View information about CD279 on UniProt.org

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