PE/Cyanine7 anti-mouse CD335 (NKp46) Antibody
- 产品名称：
- PE/Cyanine7 anti-mouse CD335 (NKp46) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 137617
- 产品应用：
- 137617
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- NKP46-IgG1 Fc fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume.? It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: immunohistochemical staining of frozen tissue sections1,2 and in vitro activation of NK cells1.
- Additional Product Notes
- BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.
- Application References
(PubMed link indicates BioLegend citation) -
- Walzer T, et al. 2007. P. Natl. Acad. Sci. USA 104:3384. (FC, Activ)
- Walzer T, et al. 2007. Nat. Immunol. 8:1337. (FC, Activ)
- Guerriero JL, et al. 2011. J. Immunol. 186:3517. (IHC) PubMed
- Product Citations
-
- Koyama M, et al. 2015. J Exp Med. 212: 1303 - 1321. PubMed
- Stegelmeier AA, et al. 2022. Biomedicines. 10:. PubMed
- Victorino F, et al. 2015. J Immunol. 195: 4973 - 4985. PubMed
- Molina-Sanchez P, et al. 2020. Gastroenterology. 2203:159. PubMed
- Fachi JL, et al. 2020. J Exp Med. 217:00:00. PubMed
- Markov SD, et al. 2021. Mol Cancer Ther. 20:2457. PubMed
- Xu B, et al. 2021. Nat Commun. 12:5908. PubMed
- Frasch S, et al. 2016. J Immunol. 197: 1425 - 1434. PubMed
- Darragh LB, et al. 2022. Nat Commun. 13:7015. PubMed
- McFarland AP, et al. 2021. Immunity. 54(6):1320-1337.e4. PubMed
- Reinfeld BI, et al. 2021. Nature. 593:282. PubMed
- Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
- Feng J,et al. 2017. Nat Commun. . 10.1038/s41467-017-01056-8. PubMed
- Wolf KG, et al. 2022. JVS Vasc Sci. 3:336. PubMed
- Isvoranu G, et al. 2019. Oncol Lett. 17:4197. PubMed
- Westrich JA, et al. 2019. Oncogene. 38:7166. PubMed
- Tian L, et al. 2022. Clin Cancer Res. 28:201. PubMed
- Koyama M et al. 2019. Immunity. 51(5):885-898 . PubMed
- Mincham KT, et al. 2021. Front Immunol. 11:601494. PubMed
- RRID
- AB_11218594 (BioLegend Cat. No. 137617) AB_11219186 (BioLegend Cat. No. 137618)
- Structure
- Single-pass type I membrane protein, 46 kD; belongs to the natural cytotoxicity receptor (NCR) family; contains 2 Ig-like (immunoglobulin-like) domains
- Distribution
-
Mature and immature NK cells, subset of NKT cells, but not on CD1d-restricted NKT cells
- Function
- NK cells activation
- Ligand/Receptor
- Viral hemagglutinins, heparan sulfate proteoglycans
- Cell Type
- NK cells, NKT cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules
- Antigen References
-
1. Colucci F and Cilio CM. 2010. Nat. Immunol. 125:60.
2. Caligiuri MA. 2008. Blood 112:461.
3. Colonna M. 2009. Immunity 31:15.
- Gene ID
- 17086 View all products for this Gene ID
- UniProt
- View information about CD335 on UniProt.org
