PE anti-mouse CD335 (NKp46) Antibody
- 产品名称：
- PE anti-mouse CD335 (NKp46) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 137603
- 产品应用：
- 137603
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- NKP46-IgG1 Fc fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: immunohistochemical staining of frozen tissue sections1,2 and in vitro activation of NK cells1.
- Application References
(PubMed link indicates BioLegend citation) -
- Walzer T, et al. 2007. P. Natl. Acad. Sci. USA 104:3384. (FC, Activ)
- Walzer T, et al. 2007. Nat. Immunol. 8:1337. (FC, Activ)
- Guerriero JL, et al. 2011. J. Immunol. 186:3517. (IHC) PubMed
- Product Citations
-
- Palacios-Arreola M, et al. 2017. Sci Rep. 10.1038/s41598-017-10135-1. PubMed
- Vogt M, et al. 2011. J Virol. 85:11567. PubMed
- Fu R, et al. 2020. Sci Rep. 10:1455. PubMed
- Li Y, et al. 2014. PLoS One. 9:86927. PubMed
- Fu B et al. 2017. Immunity. 47(6):1100-1113 . PubMed
- Cluff E, et al. 2022. Cancer Immunol Immunother. . PubMed
- Almeida AS, et al. 2021. Bio Protoc. 11:e4012. PubMed
- Victorino F, et al. 2015. J Immunol. 195: 4973 - 4985. PubMed
- Starkl P, et al. 2020. Immunity. 53(4):793-804.e9. PubMed
- Dolgova EV, et al. 2022. Int J Mol Sci. 23:. PubMed
- Fachi JL, et al. 2020. J Exp Med. 217:00:00. PubMed
- Best SA, et al. 2018. Cell Metab. 27:935. PubMed
- Li J, et al. 2020. Cancer Discov. . PubMed
- Schaffert A, et al. 2020. Front Immunol. 10:3024. PubMed
- Almeida AS, et al. 2021. Bio Protoc. 11:e4012. PubMed
- Li J, et al. 2020. Cancer Immunol Res. 0.529166667. PubMed
- Adams NM et al. 2018. Immunity. 48(6):1172-1182 . PubMed
- Wiedemann GM, et al. 2020. Cell Rep. 33:108498. PubMed
- Diaz–Salazar C, et al. 2020. Cell Rep. 32:108186. PubMed
- Progatzky F, et al. 2021. Nature. 599:125. PubMed
- Ruiz–Manzano RA, et al. 2020. Frontiers in Oncology. 0.927777778. PubMed
- Ye X, et al. 2021. Cancer Biol Med. Online ahead of print. PubMed
- Yuan X, et al. 2017. Elife. 6:e29540. PubMed
- Kang YH, et al. 2019. Nat Commun. 10:912. PubMed
- Zhao L,et al. 2017. Nat Commun. . 10.1038/s41467-017-01181-4. PubMed
- Sheppard S, et al. 2021. Cell Reports. 35(9):109210. PubMed
- Geary CD et al. 2018. Cell reports. 24(8):1949-1957 . PubMed
- Teng F, et al. 2021. Cell Rep. 37:110051. PubMed
- Liu CF, et al. 2017. Front Immunol. 1.445833333. PubMed
- Guo S, et al. 2021. Frontiers in Immunology. 11:614667. PubMed
- RRID
- AB_10552741 (BioLegend Cat. No. 137603) AB_2235755 (BioLegend Cat. No. 137604)
- Structure
- Single-pass type I membrane protein, 46 kD; belongs to the natural cytotoxicity receptor (NCR) family; contains 2 Ig-like (immunoglobulin-like) domains
- Distribution
-
Mature and immature NK cells, subset of NKT cells, but not on CD1d-restricted NKT cells
- Function
- NK cells activation
- Ligand/Receptor
- Viral hemagglutinins, heparan sulfate proteoglycans
- Cell Type
- NK cells, NKT cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules
- Antigen References
-
1. Colucci F and Cilio CM. 2010. Nat. Immunol. 125:60.
2. Caligiuri MA. 2008. Blood 112:461.
3. Colonna M. 2009. Immunity 31:15.
- Gene ID
- 17086 View all products for this Gene ID
- UniProt
- View information about CD335 on UniProt.org
