FITC anti-mouse CD335 (NKp46) Antibody
- 产品名称：
- FITC anti-mouse CD335 (NKp46) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 137605
- 产品应用：
- 137605
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- NKP46-IgG1 Fc fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: immunohistochemical staining of frozen tissue sections1,2 and in vitro activation of NK cells1.
- Application References
(PubMed link indicates BioLegend citation) -
- Walzer T, et al. 2007. P. Natl. Acad. Sci. USA 104:3384. (FC, Activ)
- Walzer T, et al. 2007. Nat. Immunol. 8:1337. (FC, Activ)
- Guerriero JL, et al. 2011. J. Immunol. 186:3517. (IHC) PubMed
- Product Citations
-
- Calabrese DR, et al. 2020. J Clin Invest. . PubMed
- Hou X, et al. 2020. Cell Reports. 28(1):172-189.e7.. PubMed
- Huang J, et al. 2021. Immunity. 54(4):673-686.e4. PubMed
- Miller CM, et al. 2020. J Virol. 94:00:00. PubMed
- Shapiro MR, et al. 2020. Front Immunol. 1.972222222. PubMed
- Piranlioglu R, et al. 2019. Nat Commun. 10:1430. PubMed
- Ellis G, et al. 2015. EMBO Rep. 16: 1203-1218. PubMed
- Zhou Y, et al. 2020. Immunity. 52(2):357-373. PubMed
- He J, et al. 2020. Cell Reports. 29(9):2718-2730.e6.. PubMed
- Lissner MM, et al. 2020. Elife. 9:00. PubMed
- Chun E, et al. 2020. Immunity. 51(5):871-884.e6.. PubMed
- Li J, et al. 2018. Immunity. 49:178. PubMed
- Marcus A et al. 2018. Immunity. 49(4):754-763 . PubMed
- Sasaki T, et al. 2020. Cell Reports. 28(1):202-217.e7.. PubMed
- Liu W, et al. 2019. Epigenetics. 1.192361111. PubMed
- Zhu Y, et al. 2021. EMBO J. 40:e105320. PubMed
- Gubin MM, et al. 2018. Cell. 175:1014. PubMed
- Kawamura A, et al. 2016. Sci Rep. 6:19464. PubMed
- Martin MD, et al. 2020. Cell Rep. 31:107508. PubMed
- Wang T et al. 2018. Immunity. 49(3):504-514 . PubMed
- Bhatt D, et al. 2021. J Exp Med. 218:. PubMed
- Lam KC, et al. 2021. Cell. 184:5338. PubMed
- Natale CA, et al. 2018. Elife. 7. PubMed
- Srivastava S, et al. 2020. Cancer Cell. 39(2):193-208.e10. PubMed
- Ukidve A, et al. 2020. Proc Natl Acad Sci U S A. 117:17727. PubMed
- Burton OT, et al. 2018. Clin Exp Allergy. 48:288. PubMed
- Rivera CA, et al. 2022. Immunity. 55:129. PubMed
- RRID
- AB_2149150 (BioLegend Cat. No. 137605) AB_2298210 (BioLegend Cat. No. 137606)
- Structure
- Single-pass type I membrane protein, 46 kD; belongs to the natural cytotoxicity receptor (NCR) family; contains 2 Ig-like (immunoglobulin-like) domains
- Distribution
-
Mature and immature NK cells, subset of NKT cells, but not on CD1d-restricted NKT cells
- Function
- NK cells activation
- Ligand/Receptor
- Viral hemagglutinins, heparan sulfate proteoglycans
- Cell Type
- NK cells, NKT cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules
- Antigen References
-
1. Colucci F and Cilio CM. 2010. Nat. Immunol. 125:60.
2. Caligiuri MA. 2008. Blood 112:461.
3. Colonna M. 2009. Immunity 31:15.
- Gene ID
- 17086 View all products for this Gene ID
- UniProt
- View information about CD335 on UniProt.org
