APC anti-mouse CD335 (NKp46) Antibody
- 产品名称：
- APC anti-mouse CD335 (NKp46) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 137607
- 产品应用：
- 137607
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- NKP46-IgG1 Fc fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Red Laser (633 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: immunohistochemical staining of frozen tissue sections1,2 and in vitro activation of NK cells1.
- Application References
(PubMed link indicates BioLegend citation) -
- Walzer T, et al. 2007. P. Natl. Acad. Sci. USA 104:3384. (FC, Activ)
- Walzer T, et al. 2007. Nat. Immunol. 8:1337. (FC, Activ)
- Guerriero JL, et al. 2011. J. Immunol. 186:3517. (IHC) PubMed
- Product Citations
-
- Glasner A,et al. 2017. Sci Rep.. 10.1038/s41598-017-12998-w. PubMed
- Hou X, et al. 2020. Cell Reports. 28(1):172-189.e7.. PubMed
- Miller CM, et al. 2020. J Virol. 94:00:00. PubMed
- Fan L, et al. 2021. Cancers (Basel). 13:. PubMed
- Yilmaz B, et al. 2021. Cell Host Microbe. 29(4):650-663.e9. PubMed
- Forte E, et al. 2020. J Cell Mol Med. . PubMed
- Hu D, et al. 2021. J Cell Mol Med. 25:2900. PubMed
- Yan X, et al. 2022. Int J Biol Sci. 18:585. PubMed
- Britton GJ et al. 2019. Immunity. 50(1):212-224 . PubMed
- Iannello A, et al. 2013. J Exp Med. 210:2057. PubMed
- Huang B, et al. 2015. PLoS One. 10: 0134715. PubMed
- Parhi L, et al. 2020. Nat Commun. 2.721527778. PubMed
- Bradley KC, et al. 2019. Cell Rep. 28:245. PubMed
- Stotesbury C, et al. 2020. J Immunol. 204:1582. PubMed
- Sibilio A, et al. 2022. iScience. 25:103790. PubMed
- Hu M, et al. 2020. Cancer Immunol Res. 8:1150. PubMed
- Taylor D, et al. 2022. Front Immunol. 13:936129. PubMed
- Rive CM, et al. 2022. Mol Ther Methods Clin Dev. 26:4. PubMed
- Yue W, et al. 2019. Nat Commun. 10:2025. PubMed
- Yao C, et al. 2018. Autophagy. 1.854861111. PubMed
- Baldwin LA, et al. 2022. Nat Commun. 13:6539. PubMed
- Muchenditsi A, et al. 2017. Am J Physiol Gastrointest Liver Physiol. 313:G39. PubMed
- Sánchez-del-Campo L, et al. 2021. J Exp Clin Cancer Res. 40:117. PubMed
- Di Pilato M, et al. 2021. Cell. 184(17):4512-4530.e22. PubMed
- Renner K, et al. 2020. Cell Reports. 29(1):135-150.e9.. PubMed
- Pisano F, et al. 2014. PLoS One. 9:103541. PubMed
- Rappe JCF, et al. 2021. J Exp Med. 218:. PubMed
- Ghosh M, et al. 2021. Cancer Cell. 39(4):494-508.e5. PubMed
- Kennedy J, et al. 2014. J Exp Med. 211:2519. PubMed
- RRID
- AB_10612749 (BioLegend Cat. No. 137607) AB_10612758 (BioLegend Cat. No. 137608)
- Structure
- Single-pass type I membrane protein, 46 kD; belongs to the natural cytotoxicity receptor (NCR) family; contains 2 Ig-like (immunoglobulin-like) domains
- Distribution
-
Mature and immature NK cells, subset of NKT cells, but not on CD1d-restricted NKT cells
- Function
- NK cells activation
- Ligand/Receptor
- Viral hemagglutinins, heparan sulfate proteoglycans
- Cell Type
- NK cells, NKT cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules
- Antigen References
-
1. Colucci F and Cilio CM. 2010. Nat. Immunol. 125:60.
2. Caligiuri MA. 2008. Blood 112:461.
3. Colonna M. 2009. Immunity 31:15.
- Gene ID
- 17086 View all products for this Gene ID
- UniProt
- View information about CD335 on UniProt.org
