Purified anti-human CD273 (B7-DC, PD-L2) Antibody
- 产品名称：
- Purified anti-human CD273 (B7-DC, PD-L2) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 329602
- 产品应用：
- 329602
- Verified Reactivity
- Human
- Reported Reactivity
- African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human PD-L2 cDNA
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
IHC-F, FA - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis.?For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 ?g per 106 cells in 100 ?l volume or 100 ?l of whole blood.
- Application References
(PubMed link indicates BioLegend citation) -
- Brown JA, et al. 2003. J. Immunol. 170:1257
- Rodig N, et al. 2003. Eur. J. Immunol. 33:3117
- Product Citations
-
- Friebel E, et al. 2020. Cell. 181(7):1626-1642.e20. PubMed
- Yonemitsu K, et al. 2022. Sci Rep. 12:12007. PubMed
- Komohara Y, et al. 2018. J Clin Exp Hematop. 58:152. PubMed
- Heesters BA, et al. 2021. J Exp Med. 218:. PubMed
- Hoffmann F, et al. 2020. Clin Epigenetics. 12:94. PubMed
- Kennedy-Darling J, et al. 2021. Eur J Immunol. 51:1262. PubMed
- Garcia de Moura R, et al. 2021. Front Immunol. 12:632667. PubMed
- Beetz O, et al. 2019. PLoS One. 14:e0220546. PubMed
- Enyindah-Asonye G, et al. 2019. Front Immunol. 10:511. PubMed
- RRID
- AB_1089010 (BioLegend Cat. No. 329602)
- Structure
- B7 Immunoglobulin superfamily, 25 kD
- Distribution
-
Dendritic cells, liver, few transformed cell lines, subset of macrophages
- Function
- Binds to PD-1 and alternative receptor; ligation on DC stimulates, inhibits T cell responses via PD-1 binding, stimulates T cells via alternative receptor binding and promotes tumor immunity
- Ligand/Receptor
- PD-1
- Cell Type
- Dendritic cells, Macrophages
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules, Immune Checkpoint Receptors
- Antigen References
-
1. Shin T, et al. 2003. J. Exp. Med. 198:31.
2. Liu X, et al. 2003. J. Exp. Med. 197:1721.
3. Carreno BM, et al. 2002. Annu. Rev. Immunol. 20:29.
- Gene ID
- 80380 View all products for this Gene ID
- UniProt
- View information about CD273 on UniProt.org
