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Brilliant Violet 421™ anti-human CD154 Antib
产品名称：
Brilliant Violet 421™ anti-human CD154 Antib
产品类别：
抗体
产品编号：
310823
产品应用：
310823
[价格]
规格 价格 库存
25tests ￥ 2580 1

产品详情

Product Details

Verified Reactivity
Human
Reported Reactivity
Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421? under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Brilliant Violet 421? excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421? is a trademark of Sirigen Group Ltd.


Learn more about Brilliant Violet?.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser
Violet Laser (405 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunofluorescence microscopy1,3?and blocking of T cell-dependent B cell differentiation1,2,4,5. The LEAF? purified antibody (Endotoxin <0.1 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 310812). For highly sensitive assays, we recommend Ultra-LEAF? purified antibody (Cat. No. 310828) with a lower endotoxin limit than standard LEAF? purified antibodies (Endotoxin <0.01 EU/?g).

Application References

(PubMed link indicates BioLegend citation)
  1. Brams P,?et al.?2001.?Int. Immunopharmacol.?1:277. (Block, IF)
  2. Rushworth SA,?et al.?2002.?Transplantation?73:635. (Block)
  3. Berner B,?et al.?2000.?Ann. Rheum. Dis.?59:190. (IF)
  4. Nordstr?m T,?et al.?2006.?J. Leukocyte Biol.?79:319. (Block)
  5. Zhang AL,?et al.2007.?Blood?doi:10.1182/blood-2007-02-076364. (Block)?PubMed
  6. Kuchen S,?et al.?2007.?J. Immunol.?179:5886.
  7. Matus-Nicodermos R,?et al.?2011.?J. Immunol.?186:2164.?PubMed
  8. Peterson VM,?et al.?2017.?Nat. Biotechnol.?35:936. (PG)
Product Citations
  1. Wenthe J, et al. 2021. Cancer Immunology Immunotherapy. . PubMed
  2. Braun J, et al. 2020. Nature. 587:270. PubMed
  3. Arunachalam PS, et al. 2021. Nature. 596:410. PubMed
  4. Romero-Olmedo AJ, et al. 2022. Nat Microbiol. 7:195. PubMed
  5. Eriksson E, et al. 2016. Gene Ther. 10.1038/gt.2016.80. PubMed
  6. Sayin I, et al. 2018. J Exp Med. 7:40286. PubMed
  7. Gao Y, et al. 2022. Immunity. 55:1732. PubMed
  8. Warthan MD, et al. 2018. Biol Reprod. 98:309. PubMed
  9. Ferreira-Gomes M, et al. 2021. Nat Commun. 12:1961. PubMed
  10. Tesch S, et al. 2020. Sci Rep. 10:21312. PubMed
RRID
AB_10933251 (BioLegend Cat. No. 310823) AB_2562721 (BioLegend Cat. No. 310824)

Antigen Details

Structure
TNF superfamily, type II transmembrane glycoprotein, cleaved as soluble CD40L, 32-39 kD
Distribution

Activated T cells

Function
B cell costimulation
Ligand/Receptor
CD40
Cell Type
T cells, Tregs
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References

1. Najafian N, et al. 2003. Expert Opin. Biol. Ther. 3:227.
2. Racke M, et al. 2002. Expert Opin. Ther. Targets. 6:275.
3. Ford G, et al. 1999. J. Immunol. 162:4037.

Gene ID
959 View all products for this Gene ID
UniProt
View information about CD154 on UniProt.org

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