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FITC anti-mouse/human Helios Antibody
产品名称：
FITC anti-mouse/human Helios Antibody
产品类别：
抗体
产品编号：
137204
产品应用：
137204
[价格]
规格 价格 库存
25tests ￥ 1980 1

产品详情

Product Details

Verified Reactivity
Mouse, Human
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Helios peptide (aa 51-107)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular flow cytometry using our True-Nuclear? Transcription Factor Staining Protocol. It is recommended that the reagent be titrated for optimal performance for each application.
For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Blue Laser (488 nm)
Application Notes

NOTE: For flow cytometric staining with this clone, True-Nuclear? Transcription Factor Buffer Set (Cat. No. 424401) offers improved staining and is highly recommended over the Foxp3 Fix/Perm Buffer Set (Cat. No. 421403) and the True-Nuclear? 10X Perm Buffer (Cat. No. 424403).

View more applications data for a different format of this clone in our Scientific Poster Library.

Application References

(PubMed link indicates BioLegend citation)
  1. Thornton AM, et al. 2010. J. Immunol. 184:1. PubMed
  2. Verhagen J and Wraith D. 2010. J. Immunol. 185:7129.
  3. Stone B, et al. 2012. Clin Immunol. 145:153. PubMed
  4. Vaeth M, et al. 2012. PNAS. 109:16258. PubMed
  5. Angin M, et al. 2014. PLoS One. 9:86920. PubMed
  6. Bedke T, et al. 2014. Immunol Cell Biol. PubMed
  7. Liu Y, et al. 2014. Am J Physiol Gastrointest Liver Physiol. 307:177. PubMed
  8. Verhagen J and Wraith DC. 2014. J. Immunol. Methods. S0022. (FC) PubMed
Product Citations
  1. Huijts C, et al. 2016. Clin Immunol. 168:47-54. PubMed
  2. Nakagome K, et al. 2011. J Immunol. 187:5077. PubMed
  3. Litjens N, et al. 2015. J Immunol. 194:5282. PubMed
  4. Vaeth M, et al. 2012. Proc Natl Acad Sci U S A. 109:16258. PubMed
  5. Shi L, et al. 2021. Immunity. . PubMed
  6. Huijts C, et al. 2015. J Immunol. 195: 2038-2045. PubMed
  7. Stone B, et al. 2012. Clin Immunol. 145:153. PubMed
  8. Britton GJ et al. 2019. Immunity. 50(1):212-224 . PubMed
  9. Trotta E, et al. 2018. Nat Med. 24:1005. PubMed
  10. Chowdhury A, et al. 2015. J Immunol. 195: 3237 - 3247. PubMed
  11. Liu Y, et al. 2014. Am J Physiol Gastrointest Liver Physiol. 307:177. PubMed
  12. Angin M, et al. 2014. PLoS One. 9:86920. PubMed
  13. Luo Y, et al. 2021. Nat Commun. 12:3913. PubMed
  14. Andersen L, et al. 2020. Cell Reports. 29(13):4447-4459.e6.. PubMed
  15. Bedke T, et al. 2014. Immunol Cell Biol. . PubMed
  16. Angin M, et al. 2013. J Vis Exp. 75: 50244. PubMed
  17. Chachage M, et al. 2016. J Virol. 90: 8954 - 8967. PubMed
  18. Long S, et al. 2011. J Immunol. 187:3511. PubMed
  19. Ickrath P, et al. 2019. Biomed Rep. 10:119. PubMed
  20. Halim TYF et al. 2018. Immunity. 48(6):1195-1207 . PubMed
  21. Ickrath P, et al. 2018. Int J Mol Med. 42:1116. PubMed
  22. Toor SM, et al. 2018. Clin Exp Immunol. 191:189. PubMed
RRID
AB_10549181 (BioLegend Cat. No. 137204) AB_10662745 (BioLegend Cat. No. 137214)

Antigen Details

Structure
A zinc finger nuclear transcription factor of the Ikaros family, containing 2 zinc-finger domains in C-terminal region.
Distribution

Regulatory T cells (Tregs), conventional T cells, thymocytes.

Function
Plays an important role in T cell development and homeostasis, involved in tumor immunity.
Cell Type
T cells, Thymocytes, Tregs
Biology Area
Cell Biology, Immunology, Transcription Factors
Molecular Family
Nuclear Markers
Antigen References

1. Kelly CM, et al.? 1998. Curr. Biol. 8:508.
2. Dovat S, et al. 2005. J. Immunol. 175:3508.
3. Cortes M, et al. 1999. Curr. Opin. Immunol. 11:167.
4. Cai Q, et al. 2009. J. Immunol. 183:2303.
5. Zhang Z, et al. 2007. Blood 109:2190.
6. Hahm K, et al. 1998. Genes Dev. 12:782.

Gene ID
22779 View all products for this Gene ID 22807 View all products for this Gene ID
UniProt
View information about Helios on UniProt.org

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