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首页 > 抗体蛋白 > 抗体
APC anti-mouse/human Helios Antibody
产品名称：
APC anti-mouse/human Helios Antibody
产品类别：
抗体
产品编号：
137221
产品应用：
137221
[价格]
规格 价格 库存
25tests ￥ 2496 1

产品详情

Product Details

Verified Reactivity
Mouse, Human
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Helios peptide (aa 51-107)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular flow cytometry using our True-Nuclear? Transcription Factor Staining Protocol.
For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

NOTE: For flow cytometric staining with this clone, True-Nuclear? Transcription Factor Buffer Set (Cat. No. 424401) offers improved staining and is highly recommended over the Foxp3 Fix/Perm Buffer Set (Cat. No. 421403) and the True-Nuclear? 10X Perm Buffer (Cat. No. 424403).

View more applications data for a different format of this clone in our Scientific Poster Library.

Application References

(PubMed link indicates BioLegend citation)
  1. Thornton AM, et al. 2010. J. Immunol. 184:1. PubMed
  2. Verhagen J and Wraith D. 2010. J. Immunol. 185:7129.
  3. Stone B, et al. 2012. Clin Immunol. 145:153. PubMed
  4. Vaeth M, et al. 2012. PNAS. 109:16258. PubMed
  5. Angin M, et al. 2014. PLoS One. 9:86920. PubMed
  6. Bedke T, et al. 2014. Immunol Cell Biol. PubMed
  7. Liu Y, et al. 2014. Am J Physiol Gastrointest Liver Physiol. 307:177. PubMed
  8. Verhagen J and Wraith DC. 2014. J. Immunol. Methods. S0022. (FC) PubMed
Product Citations
  1. Harsha Krovi S, et al. 2020. Nat Commun. 4.790277778. PubMed
  2. Yang M, et al. 2019. Cell Physiol Biochem. 52:1178. PubMed
  3. Gupta R, et al. 2022. Front Immunol. 13:886442. PubMed
  4. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  5. Singh K, et al. 2015. Sci Rep. 14:7767. PubMed
  6. Bj?rkander S, et al. 2016. J Allergy Clin Immunol. 138: 905-908. PubMed
  7. Yue X, et al. 2019. Nat Commun. 10:2011. PubMed
  8. Fan L, et al. 2021. Gut Microbes. 13:1. PubMed
  9. Chellappa S, et al. 2016. J Leukoc Biol. 100: 5 - 16. PubMed
  10. Severance AL, et al. 2022. iScience. 25:104400. PubMed
  11. Bj?rkander S, et al. 2016. Sci Rep. 6:22083. PubMed
  12. Yang YH, et al. 2020. Cell Reports. 30(5):1515-1529.e4. PubMed
  13. Dai B, et al. 2021. Cell Reports Medicine. 2(8):100381. PubMed
  14. Chen S, et al. 2018. Nat Commun. 9:5298. PubMed
  15. Liang Z, et al. 2022. iScience. 25:105233. PubMed
  16. Wirasinha RC, et al. 2021. J Exp Med. 218: . PubMed
RRID
AB_10662535 (BioLegend Cat. No. 137221) AB_10662900 (BioLegend Cat. No. 137222)

Antigen Details

Structure
A zinc finger nuclear transcription factor of the Ikaros family, containing 2 zinc-finger domains in C-terminal region.
Distribution

Regulatory T cells (Tregs), conventional T cells, thymocytes.

Function
Plays an important role in T cell development and homeostasis, involved in tumor immunity.
Cell Type
T cells, Thymocytes, Tregs
Biology Area
Cell Biology, Immunology, Transcription Factors
Molecular Family
Nuclear Markers
Antigen References

1. Kelly CM, et al.? 1998. Curr. Biol. 8:508.
2. Dovat S, et al. 2005. J. Immunol. 175:3508.
3. Cortes M, et al. 1999. Curr. Opin. Immunol. 11:167.
4. Cai Q, et al. 2009. J. Immunol. 183:2303.
5. Zhang Z, et al. 2007. Blood 109:2190.
6. Hahm K, et al. 1998. Genes Dev. 12:782.

Gene ID
22779 View all products for this Gene ID 22807 View all products for this Gene ID
UniProt
View information about Helios on UniProt.org

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