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首页 > 抗体蛋白 > 抗体
PE anti-human FOXP3 Antibody
产品名称：
PE anti-human FOXP3 Antibody
产品类别：
抗体
产品编号：
320107
产品应用：
320107
[价格]
规格 价格 库存
25tests ￥ 2196 1

产品详情

Product Details

Verified Reactivity
Human
Reported Reactivity
Baboon, Cynomolgus, Rhesus, Pigtailed Macaque
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Full-length FOXP3 protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The FOXP3 antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular flow cytometry using our True-Nuclear? Transcription Factor Staining Protocol. For flow cytometric staining, the suggested use of this reagent is 5 ?L per million cells in 100 ?L staining volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections1 and formalin-fixed paraffin-embedded sections1,8,19-20, and Western blotting1. The binding of 206D to FOXP3 can be partially blocked by 259D, but 206D does not show significant blocking effect on 259D binding.

NOTE: For flow cytometric staining with this clone, True-Nuclear? Transcription Factor Buffer Set (Cat. No. 424401) offers improved staining and is highly recommended.

Application References

(PubMed link indicates BioLegend citation)
  1. Roncador G, et al. 2005. Eur. J. Immunol. 35:1681.(IHC)
  2. Yang ZZ, et al. 2006. Blood 107:3639.
  3. Liu W, et al. 2006. J. Exp. Med. 203:1701.PubMed
  4. Bollyky PL, et al. 2007. J. Immunol. 179:744.
  5. Bell MP, et al. 2007. J. Immunol. 179:1893.
  6. Tran DQ, et al. 2007. Blood doi:10.1182/blood-2007-06-094656. PubMed
  7. Gao Q,et al.2007.J Clin Oncol.25:2586.(IHC) PubMed
  8. Pillai V,et al. 2008. Blood 111:463. PubMed
  9. Zheng Y, et al. 2008. J. Immunol. 181:1683. PubMed
  10. Zonios DI, et al. 2008.Blood112:287. PubMed
  11. Kavanagh B, et al. 2008. Blood. PubMed
  12. Nevala WK, et al. 2009. Clin Cancer Res. 15:1931. PubMed
  13. Grant J, et al. 2009. Cytometry B Clin Cytom. 76:69. PubMed
  14. Nigam P, et al. 2010. J. Immunol. 184:1690. PubMed
  15. Kmieciak M, et al. 2009. J. Transl. Med. 7:89. (ICFC) PubMed
  16. Hartigan-O'Connor DJ,et al.2007.J Exp Med.204:2679. PubMed
  17. Raghaven S, et al. 2009. Ann Rheum Dis. 68:1908. PubMed
  18. Hodi FS, et al. 2014. Cancer Immunol Res. 2:632.(IHC) PubMed
  19. Sziros E, et al. 2015. Clin Cancer Res. 21:2840.(IHC) PubMed
Product Citations
  1. Cao B, et al. 2022. Nat Commun. 13:6203. PubMed
  2. Fuhrman C, et al. 2015. J Immunol. 195: 145 - 155. PubMed
  3. Ansari A, et al. 2007. J Autoimmun. 28:152. PubMed
  4. Koskimaa H, et al. 2017. Eur J Clin Microbiol Infect Dis. 10.1007/s10096-017-2958-z. PubMed
  5. Zeng W, et al. 2017. Front Immunol. 0.806944444. PubMed
  6. Marques RM, et al. 2021. Cell Death Differ. 28:3140. PubMed
  7. Delacher M, et al. 2021. Immunity. 54(4):702-720.e17. PubMed
  8. Maier L, et al. 2009. J Immunol. 182:1541. PubMed
  9. Gupta R, et al. 2022. Front Immunol. 13:886442. PubMed
  10. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  11. Porsche CE, et al. 2021. JCI Insight. 6:. PubMed
  12. Gorczynski RM, et al. 2017. Immunology. 150:418. PubMed
  13. Dean JW, et al. 2020. J Autoimmun. 108:102417. PubMed
  14. Shevyrev D, et al. 2021. Exp Ther Med. 209:21. PubMed
  15. Longhi M, et al. 2014. PLoS One. 9:87956. PubMed
  16. Dang Y, et al. 2007. Clin Cancer Res . 1.932638889. PubMed
  17. Zhang B, et al. 2021. Nat Biomed Eng. 5:1288. PubMed
  18. Parsons E, et al. 2016. PLoS One. 11:e0167841. PubMed
  19. Luo Y, et al. 2021. Nat Commun. 12:3913. PubMed
  20. OConnor RA, et al. 2021. OncoImmunology. 10(1):1940675. PubMed
  21. Van Zeebroeck L, et al. 2021. Front Immunol. 12:655122. PubMed
  22. Platten M, et al. 2021. Nature. 592:463. PubMed
  23. Sun J, et al. 2016. Sci Rep. 6:35855. PubMed
  24. Subudhi SK, et al. 2021. J Immunother Cancer. 9:. PubMed
  25. Fang F, et al. 2021. Cell Rep. 37:109981. PubMed
  26. Wang T et al. 2018. Immunity. 49(3):504-514 . PubMed
  27. Lai Y, et al. 2022. Clin Transl Med. 12:e999. PubMed
  28. Weinberg A, et al. 2015. PLoS One. 10:122431. PubMed
  29. Zhai Y, et al. 2018. Autophagy. 1.714583333. PubMed
  30. Zonios D, et al. 2008. Blood. 112:287. PubMed
  31. Wang H, et al. 2019. Stem Cells Int. 2019:4686132. PubMed
  32. Dhandapani H, et al. 2021. J Gynecol Oncol. 32:e59. PubMed
RRID
AB_492987 (BioLegend Cat. No. 320107) AB_492986 (BioLegend Cat. No. 320108)

Antigen Details

Structure
Forkhead/winged-helix transcription factor family, approximately 50 kD, contains zinc finger and forkhead domains
Distribution

Nuclear; expressed in T regulatory cells

Function
Transcription factor proposed to be a master regulatory gene in T regulatory cell development and a critical factor for immune homeostasis
Interaction
Interacts with DNA
Cell Type
Tregs
Biology Area
Cell Biology, Immunology, Transcription Factors
Molecular Family
Nuclear Markers
Antigen References

1. Hori S, et al. 2003. Science 299:1057.
2. Gandhi R, et al. 2010. Nat. Immunol. 11:846.

Regulation
FOXP3 is present at high levels in T regulatory cells, it can also be induced by T cell activation.
Gene ID
50943 View all products for this Gene ID
UniProt
View information about FOXP3 on UniProt.org

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