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PE anti-mouse CD88 (C5aR) Antibody
产品名称：
PE anti-mouse CD88 (C5aR) Antibody
产品类别：
抗体
产品编号：
135805
产品应用：
135805
[价格]
规格 价格 库存
50µg ￥ 1752 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
mC5aR transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 ?g per 106 cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications for the relevant formats include: blocking of C5a binding.

Application References

(PubMed link indicates BioLegend citation)
  1. Godau J, et al. 2004. J. Immunol. 173:3437.
  2. Shushakova N, et al. 2002. J. Clin. Invest. 110:1823.
  3. Kim SH, et al. 2013. Int Immunol. 25:623. PubMed
Product Citations
  1. Leach SM, et al. 2020. Cell Rep. 33:108337. PubMed
  2. Mehta G, et al. 2015. J Immunol. 194:5446. PubMed
  3. Neupane AS, et al. 2020. Cell. 183(1):110-125.e11. PubMed
  4. Kim SH, et al. 2021. Cell Reports. 35(2):108995. PubMed
  5. Medler TR et al. 2018. Cancer cell. 34(4):561-578 . PubMed
  6. Monteran L, et al. 2022. Nat Commun. 13:5797. PubMed
  7. Hoogendijk AJ, et al. 2020. Cell Reports. 29(8):2505-2519. PubMed
  8. Bosmann M, et al. 2012. J Immunol. 188:5086. PubMed
  9. Kim S, et al. 2013. Int Immunol. 25:623. PubMed
  10. Izumi G, et al. 2021. Nat Commun. 12:5029. PubMed
  11. Taylor L, et al. 2016. PLoS One. 11: 0160685. PubMed
  12. Bisht K, et al. 2014. Biochem Biophys Res Commun. 449:94. PubMed
  13. Bosteels C, et al. 2020. Immunity. 52(6):1039-1056.e9.. PubMed
  14. Zheng QY, et al. 2019. Front Immunol. 10:1866. PubMed
  15. Giles DA, et al. 2018. J Clin Invest. 128:5322. PubMed
  16. Deniset JF et al. 2019. Immunity. 51(1):131-140 . PubMed
  17. Zheng QY, et al. 2020. FASEB J. 34:10590. PubMed
RRID
AB_2067285 (BioLegend Cat. No. 135805) AB_2243735 (BioLegend Cat. No. 135806)

Antigen Details

Structure
Single chain protein with seven membrane-spanning regions, 43 kD.
Distribution

Neutrophils, eosinophils, monocytes, glial cells, cerebellar granule cells, cardiomyocytes, and vascular endothelial cells.

Function
After C5a binding, the CD88 signal results in chemotaxis, granule enzyme release and superoxide anion production.
Interaction
CD88 is coupled to heterotrimeric G proteins such as Gi, The signal transduced by CD88 results in the activation of PLCβ, PI-3 kinase, and PLA2, among other molecules.
Bioactivity
Chemotaxis, degranulation.
Cell Type
Dendritic cells, Endothelial cells, Eosinophils, Monocytes, Neutrophils
Biology Area
Cell Biology, Cell Motility/Cytoskeleton/Structure, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Molecular Family
CD Molecules
Antigen References

1. Schraufstatter IU, et al. 2009. J. Immunol. 182:3827.
2. Ippel JH, et al. 2009. J. Biol. Chem. 284:12363.
3. Monk PN, et al. 2007. Br. J. Pharmacol. 152:429.
4. Griffin RS, et al. 2007. J. Neurosci. 27:8699.
5. Lee H, et al. 2006. Nat. Biotechnol. 24:1279.
6. Buck E and Wells JA, et al. 2005. P. Natl. Acad. Sci. USA 102:2719.

Gene ID
12273 View all products for this Gene ID
UniProt
View information about CD88 on UniProt.org

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