Purified anti-Caspase-8 Antibody
- 产品名称：
- Purified anti-Caspase-8 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 645501
- 产品应用：
- 645501
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Full length caspase-8 fusion protein
- Formulation
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC, ELISA - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 0.5-1 ?g antibody per ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Sanchez I et al. 1999. Neuron. 22:623
- Li H, et al. 1998. Cell 94:491
- Product Citations
-
- Huangfu J, et al. 2021. Cell Death Dis. 12:386. PubMed
- Khaiboullina S, et al. 2019. Front Pharmacol. 10:642. PubMed
- RRID
- AB_2068466 (BioLegend Cat. No. 645501)
- Structure
- Full length protein of 55kd. Contains two homologous domains of DED (death effector domain) of FADD. The remainder of the protein is similar to the CED-3 subfamily of caspases.
- Distribution
-
Expressed in multiple isoforms in multiple tissues. Relatively high level in peripheral leucocytes.
- Function
- Caspase-8 is involved in apoptosis mediated by CD95 and TNFR-1.
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Neuroscience
- Antigen References
-
1. Muzio M et al. 1996. Cell 817-827
2. Cohen GM. 1997. Biochem J 326:1
- Gene ID
- 841 View all products for this Gene ID
- UniProt
- View information about Caspase-8 on UniProt.org
