Purified anti-mouse TIGIT (Vstm3) Antibody
- 产品名称：
- Purified anti-mouse TIGIT (Vstm3) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 142101
- 产品应用：
- 142101
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Joller N, et al. 2010. J. Immunol. 186:1338.
- Product Citations
-
- Arnold IC, et al. 2019. PLoS Pathog. 15:e1007866. PubMed
- Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
- Wei SC et al. 2017. Cell. 170(6):1120-1133 . PubMed
- Shaffer TM, et al. 2021. Clin Cancer Res. 27:1932. PubMed
- Muhammad F, et al. 2020. J Autoimmun. 111:102441. PubMed
- RRID
- AB_10983067 (BioLegend Cat. No. 142101) AB_10960124 (BioLegend Cat. No. 142102)
- Structure
- Type I transmembrane protein, 26 kD, member of the CD28 family. Contains 1 Ig-like domain and 1 cytoplasmic ITIM motif.
- Distribution
-
Activated T cells, follicular T helper cells, NK, memory T cells, Tregs.
- Function
- Negative regulator of T cell activation and proliferation. Induction of tolerogenic dendritic cells.
- Ligand/Receptor
- CD155 (PVR) and CD112 (PVRL2).
- Cell Type
- Dendritic cells, NK cells, T cells, Tregs
- Biology Area
- Immunology, Inhibitory Molecules
- Molecular Family
- Adhesion Molecules, Immune Checkpoint Receptors
- Antigen References
-
1. Levin SD, et al. 2011. Eur. J. Immunol. 41:902.
2. Yu X, et al. 2009. Nat. Immunol. 10:48.
3. Stanietsky N, et al. 2009. P. Natl. Acad. Sci. USA 106:17858.
- Gene ID
- 100043314 View all products for this Gene ID
- UniProt
- View information about TIGIT on UniProt.org
