Brilliant Violet 421™ anti-mouse TIGIT (Vstm
- 产品名称：
- Brilliant Violet 421™ anti-mouse TIGIT (Vstm
- 产品类别：
- 抗体
- 产品编号：
- 142111
- 产品应用：
- 142111
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421? under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC -?Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
Brilliant Violet 421? excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421? is a trademark of Sirigen Group Ltd.?
Learn more about Brilliant Violet?.
This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents. - Excitation Laser
- Violet Laser (405 nm)
- Application References
(PubMed link indicates BioLegend citation) -
- Joller N, et al. 2010. J. Immunol. 186:1338.
- Product Citations
-
- Hinterbrandner M, et al. 2021. JCI Insight. 6:e151797. PubMed
- Markov SD, et al. 2021. Mol Cancer Ther. 20:2457. PubMed
- Marjanovic ND, et al. 2020. Cancer Cell. 38(2):229-246.e13. PubMed
- Wang S, et al. 2021. Parasite. 28:13. PubMed
- RRID
- AB_2687311 (BioLegend Cat. No. 142111)
- Structure
- Type I transmembrane protein, 26 kD, member of the CD28 family. Contains 1 Ig-like domain and 1 cytoplasmic ITIM motif.
- Distribution
- Activated T cells, follicular T helper cells, NK, memory T cells, Tregs.
- Function
- Negative regulator of T cell activation and proliferation. Induction of tolerogenic dendritic cells.
- Ligand/Receptor
- CD155 (PVR) and CD112 (PVRL2).
- Cell Type
- Dendritic cells, NK cells, T cells, Tregs
- Biology Area
- Immunology, Inhibitory Molecules
- Molecular Family
- Adhesion Molecules, Immune Checkpoint Receptors
- Antigen References
-
1. Levin SD, et al. 2011. Eur. J. Immunol. 41:902.
2. Yu X, et al. 2009. Nat. Immunol. 10:48.
3. Stanietsky N, et al. 2009. P. Natl. Acad. Sci. USA 106:17858.
- Gene ID
- 100043314 View all products for this Gene ID
- UniProt
- View information about TIGIT on UniProt.org
