Purified anti-human erbB3/HER-3 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 2472	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

NIH-3T3 cells transfected with human erbB3/HER3

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

FC - Quality tested
ICC - Verified

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations

Jenke R, et al. 2020. Int J Mol Sci. 22:. PubMed
Hutt M, et al. 2018. Oncotarget. 9:11322. PubMed
Rau A, et al. 2021. MAbs. 1902034:13. PubMed

RRID

AB_756156 (BioLegend Cat. No. 324702)

Antigen Details

Structure: Member of the epidermal growth factor receptor family. A receptor tyrosine kinase containing 4 furin-like repeats, 2 cheY receiver domains, and a tyrosine kinase domain. Predicted molecular weight approximately 148 kD
Distribution: Widely expressed in many tissues including kidney, lung, brain, placenta, skin and stomach. Forms constitutively active heterodimers with erbB2/HER2 in a subset of human mammary tumors; expression of erbB3/HER3 reported be linked to favorable outcome in b
Function: Induces extensive signaling cascade that can regulate growth and possibly differentiation
Ligand/Receptor: Heregulin
Modification: Extensively phosphorylated T873 and S1123 (by cdk5); Y1199, Y1262, Y1289, Y1328
Biology Area: Cancer Biomarkers, Cell Biology, Immunology, Neuroscience, Synaptic Biology
Molecular Family: Adhesion Molecules, Cytokine/Chemokine Receptors
Antigen References: 1. Carraway KL, et al. 1994. J. Biol. Chem. 269:14303.
2. Kraus MH, et al. 1989. Proc. Natl. Acad. Sci. USA 86:9193.
3. Chan SD, et al. 1995. J. Biol. Chem. 270:22608.
4. Tanner B, et al. 2006. J. Clin. Oncol. (Epub Aug. 8 2006)
Gene ID: 2065 View all products for this Gene ID
UniProt: View information about erbB3/HER-3 on UniProt.org

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