APC anti-human erbB3/HER-3 Antibody
- 产品名称：
- APC anti-human erbB3/HER-3 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 324707
- 产品应用：
- 324707
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 1704 |
1 |
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- NIH-3T3 cells transfected with human erbB3/HER3
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Red Laser (633 nm)
- Product Citations
-
- De Bacco F, et al. 2021. Cell Reports. 36(4):109455. PubMed
- Wu J et al. 2018. Cell reports. 25(7):1966-1981 . PubMed
- Guo D, et al. 2022. Elife. 11:. PubMed
- RRID
- AB_2099568 (BioLegend Cat. No. 324707) AB_2099567 (BioLegend Cat. No. 324708)
- Structure
- Member of the epidermal growth factor receptor family. A receptor tyrosine kinase containing 4 furin-like repeats, 2 cheY receiver domains, and a tyrosine kinase domain. Predicted molecular weight approximately 148 kD
- Distribution
-
Widely expressed in many tissues including kidney, lung, brain, placenta, skin and stomach. Forms constitutively active heterodimers with erbB2/HER2 in a subset of human mammary tumors; expression of erbB3/HER3 reported be linked to favorable outcome in b
- Function
- Induces extensive signaling cascade that can regulate growth and possibly differentiation
- Ligand/Receptor
- Heregulin
- Modification
- Extensively phosphorylated T873 and S1123 (by cdk5); Y1199, Y1262, Y1289, Y1328
- Biology Area
- Cancer Biomarkers, Cell Biology, Immunology, Neuroscience, Synaptic Biology
- Molecular Family
- Adhesion Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1. Carraway KL, et al. 1994. J. Biol. Chem. 269:14303.
2. Kraus MH, et al. 1989. Proc. Natl. Acad. Sci. USA 86:9193.
3. Chan SD, et al. 1995. J. Biol. Chem. 270:22608.
4. Tanner B, et al. 2006. J. Clin. Oncol. (Epub Aug. 8 2006)
- Gene ID
- 2065 View all products for this Gene ID
- UniProt
- View information about erbB3/HER-3 on UniProt.org
