APC anti-human TSLPR (TSLP-R) Antibody
- 产品名称：
- APC anti-human TSLPR (TSLP-R) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 322807
- 产品应用：
- 322807
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 1848 |
1 |
- Verified Reactivity
- Human
- Reported Reactivity
- Baboon
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human TSLP-R:Fc protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Red Laser (633 nm)
- Application Notes
For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 322805/322806) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated anti-mouse IgG (Cat. No. 405303) second step, followed by SAv-PE (Cat. No. 405204)).
- Product Citations
-
- Palamides P, et al. 2016. Dis Model Mech. 9: 985 - 997. PubMed
- Scheeren F, et al. 2009. Eur J Immunol. 40:955. PubMed
- Sugimoto H, et al. 2010. Clin Immunol. 136:205. PubMed
- Gu C, et al. 2021. Front Immunol. 12:678036. PubMed
- Hulse K, et al. 2010. J Allergy Clin Immunol. 125:247. PubMed
- Qin H, et al. 2015. Blood. 126: 629 - 639. PubMed
- Brulefert A, et al. 2021. Allergy. 76:2044. PubMed
- RRID
- AB_2085327 (BioLegend Cat. No. 322807) AB_2261041 (BioLegend Cat. No. 322808)
- Structure
- Type I membrane receptor, forms functional heterodimeric complex with IL-7R to bind TSLP. Contains WSXWS motif required for proper protein folding and a box1 motif that is important for association with the JAKs.
- Distribution
-
Expressed preferentially in myeloid cells including dendritic cells and activated monocytes, weakly expressed in T cells. Also expressed in heart, skeletal, muscle, and kidney cells.
- Function
- TSLP binding to functional receptor activates JAK2, STAT3, and STAT5 to stimulate cell proliferation. Has been implicated in the development of the hematopoietic system, dendritic cell maturation, and the maintenance and polarization of human Th2 memory T cells.
- Interaction
- Together with IL-7R binds TSLP
- Cell Type
- Dendritic cells, Monocytes, T cells, Tregs
- Biology Area
- Immunology
- Molecular Family
- Cytokine/Chemokine Receptors
- Antigen References
-
1. Reche PA, et al. 2001. J. Immunol. 167:336.
2. Tonozuka Y, et al. 2001. Cytogenet. Cell. Genet. 93:23.
3. Zhang W, et al. 2001. Biochem. Biophys. Res. Commun. 281:878.
4. Wang YH, et al. 2006. Immunity 24:827.
- Gene ID
- 64109 View all products for this Gene ID
- UniProt
- View information about TSLPR on UniProt.org
