Purified anti-Hamartin (TSC1) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 3312	1

规格

价格

库存

100µg

￥ 3312

Product Details

Verified Reactivity

Human, Mouse

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Partial human TSC1 recombinant protein (480-666 a.a.)

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 5.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

As per the Human Protein Atlas RNA level dataset, A431 is expected to have a low level of TSC1 expression.

This clone weakly cross-reacts with mouse.

Clone 1B2-2A8 does not work for IF (in-house tested).

RRID

AB_2687066 (BioLegend Cat. No. 696502)

Antigen Details

Structure: 1164 amino acids with a predicted molecular weight of 130 kD.
Distribution: Cytoplasm, Membrane
Function: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling.
Interaction: Interacts with TSC2, DOCK7, FBXW5 and TBC1D7.
Biology Area: Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Signal Transduction
Antigen References: 1. Henske EP,?et al.?2016.?Nat. Rev. Dis. Primers. 2: 16035.
2. Kwiatkowski DJ and Manning BD. 2014.?N. Engl. J. Med.?371: 778.
3. Dibble CC and Cantley LC. 2015,?Trends Cell Biol.?25:545.
4. Neuman NA and Henske EP. 2011. EMBO Mol. Med. 3:189.
5. Han JM and Sahin M. 2011.?FEBS Lett.?585:973.
Gene ID: 7248 View all products for this Gene ID
UniProt: View information about Hamartin on UniProt.org

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