Alexa Fluor® 647 anti-Histone H3 (C-terminus)
- 产品名称：
- Alexa Fluor® 647 anti-Histone H3 (C-terminus)
- 产品类别：
- 抗体
- 产品编号：
- 819407
- 产品应用：
- 819407
- Verified Reactivity
- Human, Mouse, Rat, Drosophila
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- This monoclonal antibody was raised against a peptide sequence derived from the C-terminal domain of human Histone H3 protein.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide; may contain stabilizer.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 647 under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
IHC-P - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 0.5 - 5.0 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor? 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.
View full statement regarding label licenses - Application Notes
Reactivity to Drosophila was only verified with the purified format.
- RRID
- AB_2801160 (BioLegend Cat. No. 819407) AB_2801161 (BioLegend Cat. No. 819408)
- Structure
- Histone proteins H3 and H4 bind to form a H3-H4 dimer, two of these H3-H4 dimers combine to form a tetramer. This tetramer further combines with two H2a-H2b dimers to form the compact Histone octamer core.
- Distribution
-
Nucleus
- Function
- Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
- Interaction
- Rsk-2, MSK1, GCN5 family of HATs, HDACs, PARP, SET7/9, and CARM1
- Biology Area
- Cell Biology, Chromatin Remodeling/Epigenetics, Neuroscience, Transcription Factors
- Antigen References
-
1. Chen HM,?et al.?2015.?Epigenetics and Dermatology?409.
- Gene ID
- 8350 View all products for this Gene ID
- UniProt
- View information about Histone H3 C-terminus on UniProt.org
