Purified anti-human CD170 (Siglec-5) Antibody
- 产品名称：
- Purified anti-human CD170 (Siglec-5) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 352002
- 产品应用：
- 352002
- Verified Reactivity
- Human
- Reported Reactivity
- Chimpanzee, Bonobo, Gorilla
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Extracellular region of Siglec-5
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
ELISA - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
The 1A5 antibody cross-reacts with Siglec-144.? Additional reported applications (for the relevant formats) include: ELISA2.
Clone 1A5 cross-reacts to Gorilla2
- Application References
(PubMed link indicates BioLegend citation) -
- Cornish AL, et al. 1998. Blood 92:2123.
- Nguyen DH, et al. 2006. P. Natl. Acad. Sci. USA 103:7765. (FC, ELISA)
- Connolly NP, et al. 2002. Br. J. Haematol. 119:221.
- Angata T, et al. 2006. FASEB J. 20:1964.
- Avril T, et al. 2005. J. Biol. Chem. 280:19843.
- Product Citations
-
- Tseng YW, et al. 2021. Front Cell Infect Microbiol. 613195:11. PubMed
- RRID
- AB_10896789 (BioLegend Cat. No. 352002)
- Structure
- Member of the immunoglobulin superfamily, single pass transmembrane protein, forms a 140 kD dimer; cytoplasmic domain contains two ITIM motifs
- Distribution
-
Granulocytes, monocytes/macrophages, subsets of lymphocytes, and activated dendritic cells
- Function
- Inhibitory receptor, cell adhesion
- Interaction
- SHP-1, SHP-2
- Ligand/Receptor
- α2,3- and α2,6-linked sialic acid, glycophorin A
- Cell Type
- B cells, Dendritic cells, Granulocytes, Lymphocytes, Macrophages, Monocytes
- Biology Area
- Cell Adhesion, Cell Biology, Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules, Siglec Molecules
- Antigen References
-
1. Soto PC, et al. 2010. J. Immunol. 184:4185.
2. Carlin AF, et al. 2009. J. Exp. Med. 206:1691.
3. Zhuravleva MA. 2008. J. Mol. Biol. 375:437.
- Gene ID
- 8778 View all products for this Gene ID
- UniProt
- View information about CD170 on UniProt.org
