PE anti-human CD170 (Siglec-5) Antibody
- 产品名称：
- PE anti-human CD170 (Siglec-5) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 352003
- 产品应用：
- 352003
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 1752 |
1 |
- Verified Reactivity
- Human
- Reported Reactivity
- Chimpanzee, Bonobo, Gorilla
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Extracellular region of Siglec-5
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
The 1A5 antibody cross-reacts with Siglec-144.? Additional reported applications (for the relevant formats) include: ELISA2.
Clone 1A5 cross-reacts to Gorilla2
- Application References
(PubMed link indicates BioLegend citation) -
- Cornish AL, et al. 1998. Blood 92:2123.
- Nguyen DH, et al. 2006. P. Natl. Acad. Sci. USA 103:7765. (FC, ELISA)
- Connolly NP, et al. 2002. Br. J. Haematol. 119:221.
- Angata T, et al. 2006. FASEB J. 20:1964.
- Avril T, et al. 2005. J. Biol. Chem. 280:19843.
- Product Citations
-
- Tecle E, et al. 2019. J Biol Chem. 294:11910. PubMed
- Jobe O, et al. 2016. J Leukoc Biol. 99: 1089 - 1106. PubMed
- RRID
- AB_10896433 (BioLegend Cat. No. 352003) AB_10895766 (BioLegend Cat. No. 352004)
- Structure
- Member of the immunoglobulin superfamily, single pass transmembrane protein, forms a 140 kD dimer; cytoplasmic domain contains two ITIM motifs
- Distribution
-
Granulocytes, monocytes/macrophages, subsets of lymphocytes, and activated dendritic cells
- Function
- Inhibitory receptor, cell adhesion
- Interaction
- SHP-1, SHP-2
- Ligand/Receptor
- α2,3- and α2,6-linked sialic acid, glycophorin A
- Cell Type
- B cells, Dendritic cells, Granulocytes, Lymphocytes, Macrophages, Monocytes
- Biology Area
- Cell Adhesion, Cell Biology, Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules, Siglec Molecules
- Antigen References
-
1. Soto PC, et al. 2010. J. Immunol. 184:4185.
2. Carlin AF, et al. 2009. J. Exp. Med. 206:1691.
3. Zhuravleva MA. 2008. J. Mol. Biol. 375:437.
- Gene ID
- 8778 View all products for this Gene ID
- UniProt
- View information about CD170 on UniProt.org
