Biotin anti-TFAM Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 1908	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Full-length human TFAM protein

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.

Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This antibody recognizes endogenous TFAM in human brain tissues in WB and IHC applications but does not recognize mouse TFAM.

Application References (PubMed link indicates BioLegend citation)

Wang YE, et al. 2013. PLoS One 8(8):e74513. (WB)
Caielli S, et al. 2016. J Exp Med. 213(5):697-713. (WB)

RRID

AB_2801185 (BioLegend Cat. No. 850505) AB_2801186 (BioLegend Cat. No. 850506)

Antigen Details

Structure: TFAM is synthesized as a precursor form with a mitochondrial targeting peptide, which is removed by processing after import to the mitochondria. Mature TFAM has an apparent molecular weight of ~25 kD. Alternative splicing results in multiple transcript variants.
Distribution: Tissue distribution: Central nervous system, skin, kidney, lung, thyroid, lymph nodes, breast, esophagus, and heart.

Cellular distribution: Mitochondrion, nucleus, and cytosol.
Function: TFAM functions in mitochondrial transcription regulation, and DNA replication and repair.
Interaction: TFB1M, TFB2M, CLPX
Biology Area: Cell Biology, Mitochondrial Function, Neuroscience, Neuroscience Cell Markers, Transcription Factors
Molecular Family: Mitochondrial Markers
Antigen References: 1. Bestwick ML, Shadel GS. 2013.?Trends Biochem Sci?38(6):283-91.
2. Ramachandran A,?et al.?2017.?Nucleic Acids Res?45(2):861-874.
3.?Günther C,?et al.?2004.?Neurosci. Lett.?369: 219–223.
Gene ID: 7019 View all products for this Gene ID
UniProt: View information about TFAM on UniProt.org

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