APC anti-human CD140b (PDGFRβ) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100tests	￥ 3768	1

Product Details

Verified Reactivity

Human

Reported Reactivity

African Green, Baboon, Cynomolgus, Rhesus

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

NIH-3T3 cells transfected with human PDGFRbeta

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation

The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.

Concentration

Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser

Red Laser (633 nm)

Application Notes

The 18A2 monclonal antibody recognizes human CD140b also known as the platelet-derived growth factor receptor, beta polypeptide, PDGFR1, and PDGFR?. It has been shown to be useful for flow cytometric detection of CD140b.

Application References (PubMed link indicates BioLegend citation)

Vogel W, et al. 2002. Haematologica 88:126.
Arima, S., et al 2011. Development. 138:4763. PubMed.

Product Citations

Patterson AL, et al. 2020. Hum Reprod. 35:44:00. PubMed
Xu H, et al. 2019. Cell Stem Cell. 24:566. PubMed
Wong HY, et al. 2022. Nat Commun. 13:6036. PubMed
Welsh JA, et al. 2022. Cell Rep Methods. 2:100136. PubMed
Lin R, et al. 2014. Proc Natl Acad Sci U S A. 111:10137. PubMed
Meng YM, et al. 2021. Nat Commun. 12:6011. PubMed

RRID

AB_2162787 (BioLegend Cat. No. 323608)

Antigen Details

Structure: Cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. The identity of the growth factor bound to the receptor determines whether the functional receptor is a homodimer or heterodimer composed of both PDGFR1 and PD
Distribution: Widely expressed on a variety of mesenchymal-derived cells. Preferentially expressed in medulloblastoma.
Function: Stimulation of cell proliferation; mitogenic activity for cells of mesenchymal origin. Has been implicated in atherogenesis and oncogenesis.
Interaction: Interacts with a number of kinases (including Raf-1, NCK1, FAK, Fyn, others) as well as adaptor molecules and signaling intermediates (Grb2, Grb4, RasGAP, SHP2, SHC1, Crk, others). Has also been shown to associate with integrin β3 and nexin sorting m
Ligand/Receptor: Binds to B-chain containing PDGF molecules as well as protease-activated PDGF-C
Modification: Multiple tyrosine phosphorylation sites (Y549, Y581, Y716, Y740, Y751, Y763, Y771, Y775, Y857, Y1009, Y1021)
Cell Type: Embryonic Stem Cells, Mesenchymal cells, Mesenchymal Stem Cells
Biology Area: Angiogenesis, Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family: CD Molecules, Cytokine/Chemokine Receptors
Antigen References: 1. Claesson-Welsh L, et al. 1988. Mol. Cell Biol. 8:3476.
2. Gronwald RG, et al. 1988. Proc. Natl. Acad. Sci. USA 85:3435.
3. Gilbertson DG, et al. 2001. J. Biol. Chem.276:27406.
4. Seifert RA, et al. 1989. J. Biol. Chem. 264:8771.
5. Kanakaraj P, et al. 1991. Biochemistry 30:1761.
Gene ID: 5159 View all products for this Gene ID
UniProt: View information about CD140b on UniProt.org

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