PE anti-human CD140a (PDGFRα) Antibody
- 产品名称：
- PE anti-human CD140a (PDGFRα) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 323505
- 产品应用：
- 323505
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 1296 |
1 |
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- NIH 3T3 cells transfected with human PDGFRalpha
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application References
(PubMed link indicates BioLegend citation) -
- Miyazaki S et al. In:Leukocyte Typing VI Kishimoto et al. Eds, Garland Publishing Inc, New York 1998 pp 3-20.
- Lottaz C, et al. 2010. Cancer Res. 70:2030. PubMed
- Ricono JM, et al. 2009. Am. J. Physiol. Renal Physiol. 296:F406. (IF)
- Guarnerio J, et al. 2015. Cancer Discov. 5:396. PubMed
- Product Citations
-
- De Bacco F, et al. 2021. Cell Reports. 36(4):109455. PubMed
- Fujimoto T, et al. 2020. Cell Rep. 32:108130. PubMed
- Baio JM, et al. 2017. Transplant Direct. 3:e153. PubMed
- Yamanaka S, et al. 2021. STAR Protocols. 2(1):100314. PubMed
- Saison‐Ridinger M, et al. 2017. PLoS One. 10.1371/journal.pone.0189051. PubMed
- Liau BB et al. 2017. Cell stem cell. 20(2):233-246 . PubMed
- Koide M, et al. 2018. Tohoku J Exp Med. 244:15:00. PubMed
- Lottaz C, et al. 2010. Cancer Res. 70:2030. PubMed
- Guarnerio J, et al. 2015. Cancer Discovery. 5:396. PubMed
- Xu S, et al. 2018. Mol Cancer Ther. 17:1291. PubMed
- Liu X, et al. 2022. Cell Discov. 8:58. PubMed
- Dmitrieva RI, et al. 2019. Stem Cells Int. 2019:5690345. PubMed
- Morales Pantoja IE, et al. 2020. PLoS One. 15:e0233980. PubMed
- Liu J, et al. 2020. Cell Mol Gastroenterol Hepatol. . PubMed
- Zeltner N, et al. 2016. Nat Med. 22:1421-1427. PubMed
- RRID
- AB_2252226 (BioLegend Cat. No. 323505) AB_2268113 (BioLegend Cat. No. 323506)
- Structure
- Cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family.
- Distribution
-
Widely expressed on a variety of mesenchymal-derived cells.
- Function
- Stimulation of cell proliferation; mitogenic activity for cells of mesenchymal origin. Knock-out studies have implicated an essential role for CD140a in kidney development. Has been implicated in basal cell carcinoma and gastric stromal cell tumors.
- Interaction
- Interacts with Crk, as well as a variety of adaptor molecules and signaling intermediates (Grb2, Grb14, SHP2, others). Has also been shown to associate with integrin β3, caveolin-1, and nexin sorting molecules
- Ligand/Receptor
- Binds to A-chain containing PDGF molecules and protease-activated PDGF-C molecules
- Modification
- Multiple tyrosine phosphorylation sites (Y720, Y731, Y742, Y754, Y762, Y767, Y768, Y988, Y993, Y1018)
- Cell Type
- Embryonic Stem Cells, Mesenchymal cells, Mesenchymal Stem Cells, Neural Stem Cells
- Biology Area
- Angiogenesis, Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Stem Cells
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1. Gronwald RG, et al. 1988. Proc. Natl. Acad. Sci. USA 85:3435.
2. Gilbertson DG, et al. 2001. J. Biol. Chem. 276:27406.
3. Seifert RA, et al. 1989. J. Biol. Chem. 264:8771.
4. Rupp E, et al. 1994. Eur. J. Biochem. 225:29.
- Gene ID
- 5156 View all products for this Gene ID
- UniProt
- View information about CD140a on UniProt.org
