Purified anti-human CD227 (MUC-1) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 1692	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Jurkat cells transfected with MUC1

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/mL

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

FC - Quality tested
ICC, IHC-P - Verified

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 ?g per million cells in 100 ?L?volume.?For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1?- 10??g/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This clone shows stronger binding to the glycosylated compared to the non-glycosylated peptide¹.

Application References (PubMed link indicates BioLegend citation)

Song W, et al. 2012. Int. J Oncol. 41:1977. PubMed

Product Citations

Hinohara K, et al. 2018. Cancer Cell. 34:939. PubMed
Murad JP, et al. 2018. Front Immunol. 1.95. PubMed
Huerta–Nu? ez LFE, et al. 2019. Sci Rep. 9:6419. PubMed
Ding L, et al. 2019. Nat Commun. 10:4182. PubMed

RRID

AB_2561641 (BioLegend Cat. No. 355601) AB_2561642 (BioLegend Cat. No. 355602)

Antigen Details

Structure: 500-1000 kD proteoglycan (glycosylated form)
Distribution: Activated T cells, mucosal epithelial cells, aberrantly expressed in most breast cancers
Interaction: Complexes with SOS1 and Grb2 in RAS signaling
Ligand/Receptor: ICAM-1 and Her2/neu (ErbB2)
Cell Type: Dendritic cells, Epithelial cells, T cells
Biology Area: Immunology, Innate Immunity
Molecular Family: CD Molecules
Antigen References: 1. Gendler SJ. 2001. J. Mammary Gland Biol. Neoplasia. 6:339.
2. Agrawal B, et al. 1998. Cancer Res. 58:4079.
3. Rahn JJ, et al. 2004. J. Biol. Chem. 279:29386.
Gene ID: 4582 View all products for this Gene ID
UniProt: View information about CD227 on UniProt.org

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