Purified anti-human CD172a (SIRPα) Antibody
- 产品名称：
- Purified anti-human CD172a (SIRPα) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 372102
- 产品应用：
- 372102
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- KG1a cells.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Majdic O, et al. 1981. Blood. 58:1127.
- Product Citations
-
- Roussel M, et al. 2021. Cell Reports Medicine. 2(6):100291. PubMed
- RRID
- AB_2629807 (BioLegend Cat. No. 372102)
- Structure
- Type I transmembrane protein, 85-90 kD, one V-set Ig-like and two C-set Ig-like domains in the extracellular portion, two ITIM motifs and a proline-rich region in the cytoplasmic tail.
- Distribution
-
Monocytes, macrophages, granulocytes, dendritic cells, neurons and by cardiomyocytes derived from human pluripotent stem cells.
- Function
- Negative regulation of receptor tyrosine kinase-coupled signaling, mediates macrophage multinucleation, involved in neuronal survival.
- Ligand/Receptor
- CD47, SP-A, and SP-D.
- Cell Type
- Dendritic cells, Granulocytes, Macrophages, Monocytes, Neurons
- Biology Area
- Cell Biology, Immunology, Neuroscience Cell Markers
- Molecular Family
- CD Molecules
- Antigen References
-
1. Lv Z, et al. 2015. J. Immunol. 195:661.
2. Hatherley D, et al. 2014. J. Biol. Chem. 289:10024.
3. Zen K, et al. 2013. Nat. Commun. 4:2436.
4. Baba N, et al. 2013. J. Exp. Med. 210:1251.
5. Barclay AN, Brown MH. 2006. Nat. Rev. Immunol. 6:457.
- Gene ID
- 140885 View all products for this Gene ID
- UniProt
- View information about CD172alpha on UniProt.org
