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FITC anti-human CD206 (MMR) Antibody
产品名称：
FITC anti-human CD206 (MMR) Antibody
产品类别：
抗体
产品编号：
321103
产品应用：
321103
[价格]
规格 价格 库存
25tests ￥ 1272 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Purified human mannose receptor
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Blue Laser (488 nm)
Application Notes

The 15-2 antibody blocks the interaction of MMR with its ligand, and inhibits mannose receptor-mediated degradation of t-PA by macrophages. Additional reported applications of this antibody (for the relevant formats) include: Western blotting1, blocking of ligand binding1,2, immunofluorescence3, and immunohistochemical staining of acetone-fixed frozen tissue sections1. The Utra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 321149 and 321150).

Application References

(PubMed link indicates BioLegend citation)
  1. Noorman F, et al. 1997. J. Leukocyte Biol. 61:63. (WB, IHC, Block)
  2. Barrett-Bergshoeff M, et al. 1997. Thromb Haemost. 77:718. (Block)
  3. Kato M, et al. 2007. J. Immunol. 179:6052. (IF)
Product Citations
  1. Argüello RJ, et al. 2020. Cell Metab. 32:1063. PubMed
  2. Feuerer N, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  3. Conforti A, et al. 2021. PLoS One. 16:e0259894. PubMed
  4. Yoshimori M, et al. 2021. Cancers (Basel). 13:. PubMed
  5. Nyazika TK, et al. 2022. Front Immunol. 13:992659. PubMed
  6. Ma C, et al. 2022. Proc Natl Acad Sci U S A. 119:. PubMed
  7. Teng YY, et al. 2022. Front Bioeng Biotechnol. 10:902894. PubMed
  8. Shen M, et al. 2018. Int J Oncol. 53:317. PubMed
  9. Xu G, et al. 2022. Cell Death Dis. 13:888. PubMed
  10. Zhang Q, et al. 2013. Clin Cancer Res. 15:3176. PubMed
  11. Aung A, et al. 2020. Cancer Res. 80:263. PubMed
  12. Dai X, et al. 2021. Bioact Mater. 1.659027778. PubMed
  13. Gelsomino L, et al. 2022. Int J Mol Sci. 23:. PubMed
  14. Mansouri S, et al. 2020. Mucosal Immunol. 0.954861111. PubMed
  15. Serhan J 2012. Blood. 120:e60. PubMed
  16. Rodriguez-Perdigon M, et al. 2022. Macromol Biosci. 22:e2200168. PubMed
  17. Herter S, et al. 2013. Mol Cancer Ther. 12:2031. PubMed
  18. Krakow S, et al. 2019. Front Immunol. 10:1484. PubMed
  19. Ball M, et al. 2016. PLoS One. 11: 0149600. PubMed
  20. Wu JJ, et al. 2022. Cell Death Dis. 13:527. PubMed
  21. Tyagi A, et al. 2021. Nat Commun. 12:474. PubMed
  22. Winkler C, et al. 2021. JCI Insight. 6:. PubMed
  23. Ronaghan NJ, et al. 2022. PLoS One. 17:e0276013. PubMed
  24. Mifuji K, et al. 2017. Bone Joint Res. 10.1302/2046-3758.68.BJR-2016-0338.R1. PubMed
RRID
AB_571904 (BioLegend Cat. No. 321103) AB_571905 (BioLegend Cat. No. 321104)

Antigen Details

Structure
Type I membrane protein, Pattern Recognition Receptor (PRR) family, C-type lectin superfamily, 162-175 kD
Distribution

Macrophages, dendritic cells, hepatic and lymphatic endothelial cells

Function
Pathogen binding, facilitate phagocytosis and endocytosis, macrophage activation and antigen presentation
Ligand/Receptor
Mannose, fucose, N-acetyl glucosamine
Cell Type
Dendritic cells, Endothelial cells, Macrophages
Biology Area
Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers
Molecular Family
CD Molecules
Antigen References

1. Mason D, et al. Eds. 2002. Leukocyte Typing VII. Oxford University Press. p303
2. Wileman TE, et al. 1986. P. Natl. Acad. Sci. USA 83:2501.
3. Apostolopoulos V and McKenzie IF. 2001. Curr. Mol. Med. 1:469.
4. Le Cabec V, et al. 2005. J. Leukocyte Biol. 77:934.
5. Barrett-Bergshoeff M, et al. 1997. Thromb. Haemostatis 77:718.

Gene ID
4360 View all products for this Gene ID
UniProt
View information about CD206 on UniProt.org

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