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首页 > 抗体蛋白 > 抗体
APC/Cyanine7 anti-human CD206 (MMR) Antibody
产品名称：
APC/Cyanine7 anti-human CD206 (MMR) Antibody
产品类别：
抗体
产品编号：
321119
产品应用：
321119
[价格]
规格 价格 库存
25tests ￥ 1692 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Purified human mannose receptor
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC/Cyanine7 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

The 15-2 antibody blocks the interaction of MMR with its ligand, and inhibits mannose receptor-mediated degradation of t-PA by macrophages. Additional reported applications of this antibody (for the relevant formats) include: Western blotting1, blocking of ligand binding1,2, immunofluorescence3, and immunohistochemical staining of acetone-fixed frozen tissue sections1. The Utra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 321149 and 321150).

Additional Product Notes
BioLegend is in the process of converting the name APC/Cy7 to APC/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our APC/Cyanine7 products. Please contact Technical Service if you have any questions.
Application References

(PubMed link indicates BioLegend citation)
  1. Noorman F, et al. 1997. J. Leukocyte Biol. 61:63. (WB, IHC, Block)
  2. Barrett-Bergshoeff M, et al. 1997. Thromb Haemost. 77:718. (Block)
  3. Kato M, et al. 2007. J. Immunol. 179:6052. (IF)
Product Citations
  1. Nikonova A, et al. 2020. EBioMedicine. 54:102734. PubMed
  2. Higham A, et al. 2021. Cells. 11:. PubMed
  3. Y C, et al. 2016. J Immunol . 195: 4884-91. PubMed
  4. Nam J, et al. 2021. Adv Sci (Weinh). 2002577:8. PubMed
  5. Zhang S, et al. 2020. Front Immunol. 1.757638889. PubMed
  6. Isik G, et al. 2013. PLoS One. 8:60126. PubMed
  7. Muir LA, et al. 2022. JCI Insight. 7:. PubMed
  8. Mehta AK, et al. 2021. Nat Cancer. 2:66. PubMed
  9. Castellaro AM, et al. 2019. Cancers (Basel). 11:. PubMed
  10. Norton S, et al. 2016. Clin Transl Immunology. 5: e76. PubMed
  11. Sabree SA, et al. 2021. J Immunother Cancer. 9: . PubMed
  12. Tamò L, et al. 2021. Int J Mol Sci. 22:00. PubMed
  13. Chruewkamlow N, et al. 2021. Stem Cell Res Ther. 12:520. PubMed
  14. van Doorn CLR, et al. 2021. Front Immunol. 12:712021. PubMed
  15. Cornwell WD, et al. 2018. BMC Pulm Med. 0.820138889. PubMed
  16. Martins AJ, et al. 2017. Cell Systems. 4(4):379-392.e12. PubMed
RRID
AB_2144932 (BioLegend Cat. No. 321119) AB_2144930 (BioLegend Cat. No. 321120)

Antigen Details

Structure
Type I membrane protein, Pattern Recognition Receptor (PRR) family, C-type lectin superfamily, 162-175 kD
Distribution

Macrophages, dendritic cells, hepatic and lymphatic endothelial cells

Function
Pathogen binding, facilitate phagocytosis and endocytosis, macrophage activation and antigen presentation
Ligand/Receptor
Mannose, fucose, N-acetyl glucosamine
Cell Type
Dendritic cells, Endothelial cells, Macrophages
Biology Area
Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers
Molecular Family
CD Molecules
Antigen References

1. Mason D, et al. Eds. 2002. Leukocyte Typing VII. Oxford University Press. p303
2. Wileman TE, et al. 1986. P. Natl. Acad. Sci. USA 83:2501.
3. Apostolopoulos V and McKenzie IF. 2001. Curr. Mol. Med. 1:469.
4. Le Cabec V, et al. 2005. J. Leukocyte Biol. 77:934.
5. Barrett-Bergshoeff M, et al. 1997. Thromb. Haemostatis 77:718.

Gene ID
4360 View all products for this Gene ID
UniProt
View information about CD206 on UniProt.org

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