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首页 > 抗体蛋白 > 抗体
APC anti-human Ganglioside GD2 Antibody
产品名称：
APC anti-human Ganglioside GD2 Antibody
产品类别：
抗体
产品编号：
357305
产品应用：
357305
[价格]
规格 价格 库存
25tests ￥ 1788 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Neuroblastoma cell line LAN-1
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Clone 14G2a is an isotype switch variant from parental hybridoma 14.18 (IgG3)1. Additional reported applications (for the relevant formats) include: inducing apoptosis and enhancing cytotoxicity of chemotherapeutic drugs in the neuroblastoma cell line 2. The LEAF? or Ultra-LEAF? purified antibody is recommended for use in cytotoxic and apoptotic studies (contact our custom solutions team). This clone has also been published as 14.G2a.

Application References

(PubMed link indicates BioLegend citation)
  1. Mujoo K, et al. 1989. Cancer Res. 49:2857. (Cyt)
  2. Kowalczyk A, et al. 2009. Cancer Lett. 281:171. (Apop, Cyt)
  3. Battula VL, et al. 2012. J. Clin. Invest. 122:2066. (FC)
Product Citations
  1. Barry WE, et al. 2019. Clin Cancer Res. 25:325. PubMed
  2. Zobel MJ, et al. 2020. J Immunother Cancer. 8:00. PubMed
  3. Raman S, et al. 2021. Cell Reports Medicine. 2(7):100344. PubMed
  4. Carlson PM, et al. 2021. J Immunol. 207:720. PubMed
  5. Voeller J, et al. 2019. J Immunother Cancer. 0.530555556. PubMed
RRID
AB_2563083 (BioLegend Cat. No. 357305) AB_2563084 (BioLegend Cat. No. 357306)

Antigen Details

Distribution

Neurons, mesenchymal stem cells, highly expressed in tumors of neuro-ectodermal origin, such as melanomas, gliomas, neuroblastomas, and small cell lung carcinoma

Function
Cell attachment to extracellular matrix
Cell Type
Mesenchymal cells, Neurons
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Adhesion, Cell Biology, Immunology, Neuroscience
Molecular Family
Adhesion Molecules
Antigen References

1. Tarek N, et al. 2012. J. Clin. Invest. 122:3260.
2. Matthay KK, et al. 2012. Clin. Cancer Res. 18:2740.
3. Navid F, et al. 2010. Curr. Cancer Drug Targets. 10:200.

Gene ID
2583 View all products for this Gene ID
UniProt
View information about Ganglioside GD2 on UniProt.org

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