Alexa Fluor® 647 anti-XBP-1s Antibody
- 产品名称：
- Alexa Fluor® 647 anti-XBP-1s Antibody
- 产品类别：
- 抗体
- 产品编号：
- 647505
- 产品应用：
- 647505
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 1908 |
1 |
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- XBP-1s recombinant protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 647 under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
* Alexa Fluor? 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.
View full statement regarding label licenses - Excitation Laser
- Red Laser (633 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: immunofluorescence14 and immunohistochemical staining of PFA-fixed paraffin-embedded sections1,14.
- Application References
(PubMed link indicates BioLegend citation) -
- Tsang KY, et al. 2007. PLOS Biol. 5:568. (IHC) PubMed
- Farhan H, et al. 2008. EMBO J. 27:2043 (WB) PubMed
- Farhan H, et al. 2010. J. Cell Biol. 189:997. PubMed
- Feng-Jin G, et al. 2010. Cell Signal. [Epub ahead of print]
- Wang L, et al. 2011. Hum Mol Genet. PubMed
- Li J, et al. 2011. J. Biol Chem. 286:4912. PubMed
- Wang L, et al. 2011. Hum Mol Genet. 20:1008. PubMed
- Liu Y, et al. 2011. J Biol Chem. 286:13161. PubMed
- Shirley CM, et al. 2011 Blood. 117:6297. PubMed
- Vidal RL., et al. 2012. Hum Mol Genet. PubMed
- Byrd AE, et al. 2012. J Cell Biol. 196:689. PubMed
- Dickie LJ, et al. 2012. Ann rheum Dis. 71:2035. PubMed
- Bonetti P, et al. 2013. Blood. 122:2233. PubMed
- Maestre L, et al. 2009. Haematologica. 94:419. (IF, IHC)
- Rodriguez M, et al. 2014. J Biol Chem. 289:22942. PubMed
- Product Citations
-
- Shi X, et al. 2022. NPJ Precis Oncol. 6:58. PubMed
- RRID
- AB_2563449 (BioLegend Cat. No. 647505) AB_2563450 (BioLegend Cat. No. 647506)
- Distribution
-
Ubiquitously expressed.
- Function
- Upregulated by ER stress, IL-6, and IL-4. Downregulation correlates with tumor progression in prostate cancer. Downregulated by PAX5 transcription factor.
- Biology Area
- Cell Biology
- Antigen References
-
1. Liou HC, et al. 1990. Science 247:1581.
2. Ponath PD, et al. 1993. J. Biol. Chem.268:17074.
3. Takahashi S, et al. 2002. Prostate 50:154.
- Gene ID
- 7494 View all products for this Gene ID
- UniProt
- View information about XBP-1s on UniProt.org
