Purified anti-human CCX-CKR (CCRL1) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 2892	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Full length CCX-CKR cDNA

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

FC - Quality tested
ICC, IP, Agonist - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications for the relevant formats include: immunoprecipitation of CCX-CKR from cell lysates¹, induction of CCX-CKR internalization¹?and immunofluorescence¹. 13E11 recognizes an epitope located within the first 14 amino acids of CCX-CKR.

Application References (PubMed link indicates BioLegend citation)

Takatsuka, S. et al. 2011. J. Pharmacol. Toxicol. Methods. 63:250. (IF, IP, Agonist)

Product Citations

Bryce S, et al. 2016. J Immunol. 196: 3341-3353. PubMed
Matti C, et al. 2020. Front Immunol. 11:720. PubMed

RRID

AB_2563201 (BioLegend Cat. No. 362102)

Antigen Details

Structure: G-protein-coupled seven transmembrane receptor, 40 kD.
Distribution: Stromal cells of skin-draining lymph nodes, thymic epithelial cells, immature DCs.
Function: C-C type chemokine scavenger and decoy receptor, reduces chemokine availability by sequestering them inside the cell.
Interaction: β-arrestin.
Ligand/Receptor: CCL2, CCL8, CCL13, CCL19, CCL21, and CCL25.
Cell Type: Dendritic cells, Epithelial cells
Biology Area: Immunology
Molecular Family: Cytokine/Chemokine Receptors, GPCR
Antigen References: 1. Watts AO, et al. 2013. J. Biol. Chem. 288:7169.?
2. Comerford I, et al. 2010. Blood. 116:4130.
?
Gene ID: 51554 View all products for this Gene ID
UniProt: View information about CCX-CKR on UniProt.org

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