Purified anti-Syntrophin Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 4020	1

Product Details

Verified Reactivity

Human, Mouse, Rat

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Whole purified syntrophin from Torpedo californica electric organ postsynaptic membrane.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

WB - Quality tested
ICFC, ICC, IHC-F, IP - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

The epitope has been mapped to amino acids 108-120 within the a-syntrophin PDZ domain.

Application References (PubMed link indicates BioLegend citation)

Froehner S, et al. 1987. J. Cell Biol. 104:1633. (WB, IHC)
Gee S, et al. 1998. J. Neurosci. 18:128. (IP)
Ort T, et al. 2001. EMBO 20:4013. (IP, WB)
Adams M, et al. 2001. J. Cell Biol. 155:113. (IF)
Williams M, et al. 1999. J. Cell Biol. 144:1259. (IHC)

Product Citations

Martin CA, et al. 2022. Regen Biomater. 9:rbac031. PubMed

RRID

AB_2566133 (BioLegend Cat. No. 845102)

Antigen Details

Structure: Monomer and homodimer. Syntrophins consist of a conserved domain, two pleckstin homology domains, a PDZ domain, and a highly conserved C-terminal syntrophin unique (SU) domain. Expected MW: 58 kD.
Function: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
Interaction: Interacts with the other members of the syntrophin family SNTB1 and SNTB2; SGCG and SGCA of the dystrophin glycoprotein complex; NOS1; GRB2; the sodium channel proteins SCN4A and SCN5A; F-actin and calmodulin; Interacts with MYOC.
Biology Area: Cell Biology, Neuroscience, Signal Transduction, Synaptic Biology
Molecular Family: Postsynaptic proteins
Gene ID: 6640 View all products for this Gene ID
UniProt: View information about Syntrophin on UniProt.org

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