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首页 > 抗体蛋白 > 抗体
PE anti-human CD184 (CXCR4) Antibody
产品名称：
PE anti-human CD184 (CXCR4) Antibody
产品类别：
抗体
产品编号：
306505
产品应用：
306505
[价格]
规格 价格 库存
25tests ￥ 1548 1

产品详情

Product Details

Verified Reactivity
Human, Cynomolgus, Rhesus
Reported Reactivity
African Green, Baboon, Chimpanzee, Sooty Mangabey
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
CP-MAC-infected Sup-T1 cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of paraffin-embedded tissue sections11, immunocytochemistry3, immunofluorescence microscopy2,6, and blocking of CD4-independent infection by HIV-2 and CD4-dependent infection by some T cell-tropic isolates of HIV-14,5. Clone 12G5 may not be suitable for Western blotting.10 The Ultra-LEAF? purified antibody (Endotoxin <0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. Nos. 306539 & 306540).

Application References

(PubMed link indicates BioLegend citation)
  1. McKnight A, et al. 1997. J. Virol. 71:1692.
  2. Endres MJ, et al. 1996. Cell 87:745. (Immunogen, IF)
  3. Volin MV, et al. 1998. Biochem. Biophys. Res. Commun. 242:46. (ICC)
  4. Berndt C, et al. 1998. P. Natl. Acad. Sci. USA 95:12556. (Block)
  5. Ullrich CK, et al. 2000. Blood 96:1438. (Block)
  6. Murga M, et al. 2005. Blood 105:1992. (IF)
  7. Thompson BD. 2007. J. Biol. Chem. 282:9547. (FC) PubMed
  8. Isnardi I, et al. 2010. Blood 115:5026. PubMed
  9. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  10. Fischer T, et al. 2008. PLoS One 3:e4069.
  11. Schmid BC, et al. 2004. Breast Cancer Res. Treat. 84:247. (IHC)
Product Citations
  1. Corral-Jara KF, et al. 2021. Mol Biomed. 2:9. PubMed
  2. Liu J, et al. 2022. Front Neurol. 12:807646. PubMed
  3. Guo P, et al. 2012. Biomaterials. 33:8104. PubMed
  4. Wang B, et al. 2013. Carcinogenesis. 35:282. PubMed
  5. Blengio F, et al. 2013. Immunobiology. 218:76. PubMed
  6. Li H, et al. 2016. J Immunol. 196: 4064 - 4074. PubMed
  7. Yang W, et al. 2019. iScience. 19:450. PubMed
  8. Muir L, et al. 2018. Wellcome Open Res. 2:97. PubMed
  9. Olga Alekhina, Adriano Marchese 2016. J Biol Chem. 291(50):26083-26097. PubMed
  10. Yang C, et al. 2020. J Control Release. 326:324. PubMed
  11. Wu T, et al. 2022. Cell Death Dis. 13:624. PubMed
  12. Hou P, et al. 2015. Sci Rep. 5: 15577. PubMed
  13. Chittasupho C, Anuchapreeda S, and Sarisuta N. 2017. Eur J Pharm Biopharm. 10.1016/j.ejpb.2017.07.003. PubMed
  14. Schneider T, et al. 2015. Glycobiology. 25: 812-824. PubMed
  15. Mandl M, et al. 2014. PLoS One. 9:112140. PubMed
  16. Mair B et al. 2019. Cell reports. 27(2):599-615 . PubMed
  17. Adikrisna R, et al. 2012. Gastroenterology. 143:234. PubMed
  18. Gurevich I, et al. 2020. Biol Open. . PubMed
  19. Han W, et al. 2015. Stem Cell Dev. 24: 2536-2546. PubMed
  20. Idorn M, et al. 2018. Oncoimmunology. 7:e1412029. PubMed
  21. Magri G et al. 2017. Immunity. 47(1):118-134 . PubMed
  22. Gurevich I, et al. 2020. Biol Open. . PubMed
  23. Yuan Z, et al. 2016. Cytotherapy. 18: 860-869. PubMed
  24. Houtsma R, et al. 2021. STAR Protoc. 2:100864. PubMed
  25. Jung Y, et al. 2018. Cancer Res. 78:2026. PubMed
  26. Suan D et al. 2017. Immunity. 47(6):1142-1153 . PubMed
  27. Hartmann T, et al. 2008. J Leukoc Biol. 84:1130. PubMed
  28. subtypes N 2015. Nat Commun. 6: 10183. PubMed
  29. Chen HJ, et al. 2019. J Exp Med. 216:674. PubMed
  30. Xu J, et al. 2017. Clin Cancer Res. 23:4482. PubMed
  31. Zhang B, et al. 2021. Nat Commun. 12:1714. PubMed
  32. Yin S, et al. 2015. Sci Rep. 5: 14432. PubMed
  33. Nevins AM, et al. 2017. Methods Mol Biol. 1722:151. PubMed
  34. Subramaniam N, et al. 2021. Blood Adv. 5:1259. PubMed
  35. Smith N, et al. 2017. Nat Commun. 8:14253. PubMed
  36. Bettman N, et al. 2015. Blood Cells Mol Dis. 55: 180-186. PubMed
  37. Zhang Y et al. 2018. Cell stem cell. 23(4):516-529 . PubMed
  38. He S, et al. 2021. iScience. 24:103305. PubMed
RRID
AB_314611 (BioLegend Cat. No. 306505) AB_314612 (BioLegend Cat. No. 306506)

Antigen Details

Structure
Rhodopsin family, G-protein linked seven transmembrane glycoprotein, 45 kD
Distribution

T cells and B cells, dendritic cells, monocytes, granulocytes, hematopoietic progenitors, endothelial cells

Function
B lymphopoiesis and myelopoiesis, cardiogenesis, blood vessel formation, cerebellar development
Ligand/Receptor
SDF-1 receptor, coreceptor for X4 HIV-1
Cell Type
B cells, Dendritic cells, Endothelial cells, Granulocytes, Hematopoietic stem and progenitors, Mesenchymal Stem Cells, Monocytes, Neural Stem Cells, T cells, Tregs
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Berger E, et al. 1999. Annu. Rev. Immunol. 17:657.
2. Loetscher P, et al. 2000. Adv. Immunol. 74:127.
3. Murphy P, et al. 2000. Pharmacol. Rev. 52:145.

Gene ID
7852 View all products for this Gene ID
UniProt
View information about CD184 on UniProt.org

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