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APC anti-human CD184 (CXCR4) Antibody
产品名称：
APC anti-human CD184 (CXCR4) Antibody
产品类别：
抗体
产品编号：
306509
产品应用：
306509
[价格]
规格 价格 库存
25tests ￥ 1848 1

产品详情

Product Details

Verified Reactivity
Human, Cynomolgus, Rhesus
Reported Reactivity
African Green, Baboon, Chimpanzee, Sooty Mangabey
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
CP-MAC-infected Sup-T1 cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of paraffin-embedded tissue sections11, immunocytochemistry3, immunofluorescence microscopy2,6, and blocking of CD4-independent infection by HIV-2 and CD4-dependent infection by some T cell-tropic isolates of HIV-14,5. Clone 12G5 may not be suitable for Western blotting.10 The Ultra-LEAF? purified antibody (Endotoxin <0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. Nos. 306539 & 306540).

Application References

(PubMed link indicates BioLegend citation)
  1. McKnight A, et al. 1997. J. Virol. 71:1692.
  2. Endres MJ, et al. 1996. Cell 87:745. (Immunogen, IF)
  3. Volin MV, et al. 1998. Biochem. Biophys. Res. Commun. 242:46. (ICC)
  4. Berndt C, et al. 1998. P. Natl. Acad. Sci. USA 95:12556. (Block)
  5. Ullrich CK, et al. 2000. Blood 96:1438. (Block)
  6. Murga M, et al. 2005. Blood 105:1992. (IF)
  7. Thompson BD. 2007. J. Biol. Chem. 282:9547. (FC) PubMed
  8. Isnardi I, et al. 2010. Blood 115:5026. PubMed
  9. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  10. Fischer T, et al. 2008. PLoS One 3:e4069.
  11. Schmid BC, et al. 2004. Breast Cancer Res. Treat. 84:247. (IHC)
Product Citations
  1. Gao Y, et al. 2016. Nat Methods. 10.1038/nmeth.4042. PubMed
  2. Biasci D, et al. 2020. Proc Natl Acad Sci U S A. 117:28960. PubMed
  3. Roco JA et al. 2019. Immunity. 51(2):337-350 . PubMed
  4. Xu X, et al. 2021. Molecular Cell. :. PubMed
  5. Yang C, et al. 2021. J Immunother Cancer. 9:. PubMed
  6. Isnardi I, et al. 2010. Blood. 115:5026. PubMed
  7. Gludish DW, et al. 2020. Sci Rep. 10:19900. PubMed
  8. Jayasinghe MK, et al. 2022. Theranostics. 12:3288. PubMed
  9. McQuade A, et al. 2020. Nat Commun. 4.1875. PubMed
  10. Agha O, et al. 2020. JOR Spine. 3:e1091. PubMed
  11. Beatson RE, et al. 2021. Cell Rep Med. 2:100473. PubMed
  12. Roukens AHE, et al. 2022. Nat Immunol. 23:23. PubMed
  13. Hyun Hee Lee, Vanessa Bellat, Benedict Law 2017. PLoS One. 12(2):e0171044. PubMed
  14. Huijbregts R, et al. 2013. Endocrinology. 154:1282. PubMed
  15. Ngamsri KC, et al. 2021. Int J Mol Sci. 22:. PubMed
  16. Lu P, et al. 2021. Blood Cancer J. 11:39. PubMed
  17. Taguchi A, et al. 2017. Cell Stem Cell. 21:730. PubMed
  18. Cai J, et al. 2021. eLife. 10:00. PubMed
  19. Rai MA, et al. 2020. Retrovirology. 17:35. PubMed
  20. Kempton HR, et al. 2020. Mol Cell. 184:78. PubMed
  21. Fiedorowicz M, et al. 2020. Sci Rep. 10:5379. PubMed
  22. Foight GW, et al. 2019. Nat Biotechnol. 37:1209. PubMed
  23. Bourges C, et al. 2020. EMBO Mol Med. 12:e12112. PubMed
  24. Suzuki S, et al. 2021. STAR Protocols. 2(3):100683. PubMed
  25. Toyoda M, et al. 2015. J Virol. 89: 9639-9652. PubMed
  26. Shi J, et al. 2012. Blood. 120:1624. PubMed
  27. Meng YM, et al. 2018. Oncoimmunology. 7:e1408745. PubMed
  28. Walker KL, et al. 2021. Leuk Lymphoma. 62:1167. PubMed
  29. Grosche L, et al. 2020. Viruses. 12:. PubMed
  30. Blanco-Camarillo C, et al. 2021. Front Immunol. 12:672520. PubMed
  31. Ogaki S, et al. 2015. Sci Rep. 5:17297. PubMed
  32. Nakamura M, et al. 2019. Nat Commun. 10:194. PubMed
  33. Corgnac S, et al. 2022. J Immunother Cancer. 10:. PubMed
  34. Zhang Y et al. 2018. Cell stem cell. 23(4):516-529 . PubMed
  35. Samuel RM, et al. 2020. Cell Stem Cell. 27:876. PubMed
  36. Shan L, et al. 2017. Immunity. 47:766. PubMed
  37. Rodrigues Toste de Carvalho AL, et al. 2021. Nat Protoc. 16:1802. PubMed
  38. Olety B, et al. 2021. Sci Adv. 7:eabj7398. PubMed
RRID
AB_314615 (BioLegend Cat. No. 306509) AB_314616 (BioLegend Cat. No. 306510)

Antigen Details

Structure
Rhodopsin family, G-protein linked seven transmembrane glycoprotein, 45 kD
Distribution

T cells and B cells, dendritic cells, monocytes, granulocytes, hematopoietic progenitors, endothelial cells

Function
B lymphopoiesis and myelopoiesis, cardiogenesis, blood vessel formation, cerebellar development
Ligand/Receptor
SDF-1 receptor, coreceptor for X4 HIV-1
Cell Type
B cells, Dendritic cells, Endothelial cells, Granulocytes, Hematopoietic stem and progenitors, Mesenchymal Stem Cells, Monocytes, Neural Stem Cells, T cells, Tregs
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Berger E, et al. 1999. Annu. Rev. Immunol. 17:657.
2. Loetscher P, et al. 2000. Adv. Immunol. 74:127.
3. Murphy P, et al. 2000. Pharmacol. Rev. 52:145.

Gene ID
7852 View all products for this Gene ID
UniProt
View information about CD184 on UniProt.org

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