Purified anti-c-Met Antibody
- 产品名称：
- Purified anti-c-Met Antibody
- 产品类别：
- 抗体
- 产品编号：
- 689902
- 产品应用：
- 689902
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Bacterially expressed human c-Met alpha chain.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
KO/KD-WB -?Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone 12.1 does not cross-react with mouse. Clone 12.1 recognizes the precursor and a chain c-Met; the ? chain will not be recognized by this antibody.
- RRID
- AB_2629791 (BioLegend Cat. No. 689902)
- Structure
- Heterodimer made of an alpha chain (50 kD) and a beta chain (145 kD) which are disulfide linked.
- Distribution
-
Membrane; single-pass type I membrane protein.
- Function
- Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival.
- Interaction
- Interacts with SPSB1, SPSB2, SPSB3, SPSB4, INPP5D/SHIP1, RANBP9, RANBP10, MUC20, GRB10, PTPN1 and PTPN2. When phosphorylated, interacts with STAT3, PIK3R1, SRC, PCLG1, GRB2, GAB1 and INPPL1/SHIP2.
- Ligand/Receptor
- HGF.
- Biology Area
- Cancer Biomarkers, Cell Biology, Cell Proliferation and Viability, Signal Transduction
- Molecular Family
- Protein Kinases/Phosphatase
- Antigen References
-
1. Garajová I, et al. 2015. Transl. Oncogenomics 7:13.
2. Cooper CS, et al. 1984. Nature. 311:29.
3. Furge KA, et al. 2000. Oncogene. 19:5582.
4. Ponzetto C, et al. 1994. Cell. 77(2):261-71.
- Gene ID
- 4233 View all products for this Gene ID
- UniProt
- View information about c-Met on UniProt.org
