Purified anti-TIF1β (KAP-1, TRIM28) Phospho (
- 产品名称：
- Purified anti-TIF1β (KAP-1, TRIM28) Phospho (
- 产品类别：
- 抗体
- 产品编号：
- 654101
- 产品应用：
- 654101
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Modified peptide: VKRSRpSGEGEVC.
- Formulation
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.05% sodium azide.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC?- Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 1.0 ?g per mL. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- Boonen RACM, et al. 2022. Cancer Res. 82:615. PubMed
- Storchova R, et al. 2021. FEBS J. 288:6035. PubMed
- Zu R, et al. 2021. Cell Death Dis. 12:994. PubMed
- RRID
- AB_2561781 (BioLegend Cat. No. 654101) AB_2561782 (BioLegend Cat. No. 654102)
- Structure
- An N-terminal RING-B box coiled coil (RBCC) domain most likely attributes to intermolecular structure, while two characteristic chromatin-targeting domains, a plextrin homology (PH) finger motif and bromodomain, are found in the C-terminus.
- Distribution
-
Nucleus
- Function
- TIF1β acts as a transcriptional repressor by modulating histone deacetlyation, histone H3 Ly-9 methylation, and recruitment of HP1 proteins.
- Interaction
- TIF1β was shown to form homo-oligomers in vitro, but does not form hetero-oligomers with TIF1α or TIF1γ.
- Biology Area
- Cell Biology, Chromatin Remodeling/Epigenetics, Transcription Factors
- Molecular Family
- Phospho-Proteins
- Antigen References
-
1. Messerschmidt DM, et al. 2012. Science 335:1499.
2. Chikuma S, et al. 2012. Nat. Immunol. 13:596.
- Gene ID
- 21849 View all products for this Gene ID
- UniProt
- View information about TIF1beta on UniProt.org
